The role of wall shear stress in microvascular network adaptation.
The role of wall shear stress in microvascular network adaptation.
复制标题
壁剪切应力在微血管网络适应中的作用。
DOI：
10.1007/978-1-4615-3404-4_4
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发表时间：
1992
影响因子：
--
通讯作者：
Kiani,MF
中科院分区：
文献类型：
--
作者：
Hudetz,AG;Kiani,MF
传统上，微循环对血流增加的生理状态的结构适应与氧运输或代谢的变化有关。文献中的最新发现表明，血流本身的长期变化可能影响血管生长（Hudlicka，1988）。慢性液体潴留伴心输出量升高导致动脉血管阻力进行性增加和高血压。大动脉和小动脉的血管壁肥厚已被反复证实。最近，观察到骨骼肌组织的小动脉随着时间的推移而消失（稀疏），这也可能导致总外周阻力升高（Lombard等人，1989）。这些机制的线索可以在与大动脉的长期适应相关的研究中找到（Langille和奥唐纳，1986），以及其他研究者提出的响应于增加的壁剪切应力的小动脉的急性扩张（Davies，1989）。
Traditionally, structural adaptation of the microcirculation to physiological states with increased blood flow has been associated with changes in oxygen transport or metabolism. Recent findings in the literature suggest that long term changes in blood flow per se may influence vessel growth (Hudlicka, 1988). Chronic fluid retention with elevations of cardiac output result in progressive increases of the arterial vascular resistance and hypertension. Vascular wall hypertrophy of the larger arteries and arterioles has been repeatedly demonstrated. More recently, it has been observed that small arterioles of skeletal muscle tissue disappear over time (rarefaction) which may also contribute to the elevations of the total peripheral resistance (Lombard et al, 1989). Clues to these mechanisms may be found in studies related to long term adaptation of large arteries (Langille and O’Donnell, 1986) as well as acute dilation of arterioles in response to increased wall shear stress which has been suggested by other investigators (Davies, 1989).