SUPRACHIASMATIC AND PARAVENTRICULAR CONTROL OF PHOTOPERIODISM IN SIBERIAN HAMSTERS
SUPRACHIASMATIC AND PARAVENTRICULAR CONTROL OF PHOTOPERIODISM IN SIBERIAN HAMSTERS
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DOI：
10.1152/ajpregu.1991.260.1.r90
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发表时间：
1991-01-01
影响因子：
--
通讯作者：
DEVRIES, GJ
中科院分区：
文献类型：
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作者：
BITTMAN, EL;BARTNESS, TJ;DEVRIES, GJ
在成年西伯利亚仓鼠中检查了下丘脑视交叉上核（SCN）和室旁核（PVN）病变对光周期反应的影响。 SCN 病变在长日照中减少了夜间水的摄入量，而 PVN 病变在短日照和长日照中均增加了体重和食物摄入量。 SCN 或 PVN 损伤阻止了短日照引起的身体、脂肪垫和睾丸重量以及食物摄入量的下降。 血清催乳素（PRL）水平升高，但促卵泡激素水平未升高。 促性腺激素释放激素 (GnRH)、β-内啡肽、精氨酸加压素 (AVP) 和血管活性肠多肽 (VIP) 的免疫染色神经元和纤维的分布与其他啮齿类动物相似。 短日照暴露减少了外侧隔膜、内侧杏仁核和终纹床核的 AVP 染色，但不减少丘脑 PVN 或 SCN 的 AVP 染色。 与长日照对照相比，短日照仓鼠的 β-内啡肽阳性弓状核细胞较少，且 GnRH 阳性视前细胞也较少。 VIP染色不受光周期影响。 大多数日长对免疫染色的影响被任一损伤消除。 这些结果证实了 SCN 和 PVN 在西伯利亚仓鼠几种季节反应的光周期控制中的重要性。
The effects of lesions of the suprachiasmatic (SCN) and paraventricular nuclei (PVN) of the hypothalamus on photoperiodic responses were examined in adult Siberian hamsters. SCN lesions reduced nocturnal water intake in long days, whereas PVN lesions increased body weight and food intake in both short and long days. SCN or PVN lesions blocked short-day-induced decreases in body, fat pad, and testes weights and in food intake. Serum prolactin (PRL), but not follicle-stimulating hormone, levels were increased. The distribution of immunostained neurons and fibers for gonadotropin-releasing hormone (GnRH), beta-endorphin, arginine vasopressin (AVP), and vasoactive intestinal polypeptide (VIP) resembled that of other rodent species. Short-day exposure reduced AVP staining in lateral septum, medial amygdala, and bed nucleus of the stria terminalis but not in the PVN of the thalamus or the SCN. Short-day-exposed hamsters had fewer beta-endorphin-positive arcuate nucleus cells and tended to have fewer GnRH-positive preoptic cells than long-day controls. VIP staining was unaffected by photoperiod. Most day length effects on immunostaining were eliminated by either lesion. These results establish the importance of the SCN and PVN in the photoperiodic control of several seasonal responses in Siberian hamsters.