Menopause and Rheumatic Disease.
Menopause and Rheumatic Disease.
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DOI：
10.1016/j.rdc.2016.12.011
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Scofield RH
中科院分区：
文献类型：
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作者：
Talsania M;Scofield RH
女性在 50 岁左右自然会进入更年期。关于更年期与系统性红斑狼疮、类风湿性关节炎和骨关节炎的关系有大量数据，而关于其他风湿性疾病的数据却有限。绝经年龄可能会影响风湿性疾病的风险和病程。骨质疏松症是炎症性风湿性疾病的一个组成部分，更年期会使骨质疏松症恶化。激素替代疗法已被研究，其效果因疾病而异，甚至同一疾病的不同表现也有所不同。环磷酰胺可以诱导提前绝经，但风湿性疾病中的卵巢储备功能潜在下降。
Menopause occurs naturally in women at about age 50. There is a wealth of data concerning the relationship of menopause to systemic lupus erythematosus, rheumatoid arthritis and osteoarthritis, while there are limited data concerning other rheumatic diseases. Age at menopause may affect the risk and course of rheumatic diseases. Osteoporosis, an integral part of inflammatory rheumatic diseases, is made worse by menopause. Hormone replacement therapy has been studied and its effects are varied depending upon the disease and even different manifestations within the same disease. Cyclophosphamide can induce early menopause but there is underlying decreased ovarian reserve in rheumatic diseases.