The angular gyrus in developmental dyslexia: Task-specific differences in functional connectivity within posterior cortex
The angular gyrus in developmental dyslexia: Task-specific differences in functional connectivity within posterior cortex
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DOI：
10.1111/1467-9280.00214
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发表时间：
2000-01-01
影响因子：
8.2
通讯作者：
Gore, JC
中科院分区：
文献类型：
--
作者：
Pugh, KR;Mencl, WE;Gore, JC
发育性阅读障碍的神经影像研究的汇聚证据显示，左侧大脑半球角回及其周围的后脑区域存在功能障碍。我们通过一系列系统地改变语音组装需求的打印任务，研究了角回与枕叶和颞叶相关部位之间的功能连接(协方差)。结果表明，对于阅读困难的读者来说，语言占主导地位的左半球功能连接的中断仅限于那些对组装提出明确要求的任务。相比之下，在不需要语音组装的打印任务中，阅读困难和非受损呈现的功能连接性都很强。这一发现支持了发育性阅读障碍的神经生物学异常在很大程度上证实了语音加工领域的观点。此外，研究结果还表明，在阅读困难的读者中，右脑后部区域在调节语音表现方面起到了补偿作用。
Converging evidence from neuroimaging studies of developmental dyslexia reveals dysfunction at posterior brain regions centered in and around the angular gyrus in the left hemisphere. We examined functional connectivity (covariance) between the angular gyrus and related occipital and temporal lobe sites, across a series of print tasks that systematically varied demands on phonological assembly. Results indicate that for dyslexic readers a disruption in functional connectivity in the language-dominant left hemisphere is confined to those tasks that make explicit demands on assembly. In contrast, on print tasks thar do not require phonological assembly, functional connectivity is strong for both dyslexic and nonimpaired renders. The findings support the view that neurobiological anomalies in developmental dyslexia are largely confirmed to the phonological-processing domain. In addition, the findings suggest that right-hemisphere posterior regions serve a compensatory role in mediating phonological performance in dyslexic readers.