Association Between Platelet Glycoprotein Ibα Genotype and Ischemic Cerebrovascular Disease
Association Between Platelet Glycoprotein Ibα Genotype and Ischemic Cerebrovascular Disease
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血小板糖蛋白Ibα基因型与缺血性脑血管病的相关性
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
KiyoakiWatanabe
中科院分区：
文献类型：
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作者：
AkiraSonoda;MitsuruMurata;DaisukeIto;NorioTanahashi;AtsumiOhta;YokoTada;EikoTakeshita;TadashiYoshida;IkuoSaito;MasatoshiYamamoto;YasuoIkeda;Yasuofukuuchi;KiyoakiWatanabe
背景和目的——血小板在缺血性脑血管疾病（CVD）的发展中发挥着关键作用。血小板糖蛋白 (GP) Ib/IX/V 复合物是冯·维勒布兰德因子的受体，在高剪切应力条件下血小板活化的初始阶段起主要作用。本研究旨在调查该受体的遗传变异与 CVD 患病率之间的关联。方法——分析了 200 名经脑部 CT 和/或 MRI 证实的缺血性 CVD 患者，以及 317 名没有 CVD 或心血管疾病临床证据的年龄和性别匹配的对照受试者，分析其 GPIb α 链 (GPIbα) 145Thr/Met 二态性的基因型频率。结果 — CVD 患者 (26.5%) 中 145Met 基因型（T/M 和 M/M）的出现频率高于对照组（14.2%，P=0.0005）。基因型效应在<60岁或无后天性心血管危险因素的人群中更为明显。不吸烟女性的优势比...
Background and Purpose—Platelets play pivotal roles in the development of ischemic cerebrovascular disease (CVD). The platelet glycoprotein (GP) Ib/IX/V complex is a receptor for von Willebrand factor, which plays a major role in the initial phase of platelet activation under high shear stress conditions. This study was designed to investigate the association between a genetic variation of this receptor and the prevalence of CVD. Methods—Two hundred patients with ischemic CVD, as confirmed by brain CT and/or MRI, and 317 age- and sex-matched control subjects without clinical evidence of CVD or cardiovascular disease were analyzed for their genotype frequencies of the 145Thr/Met dimorphism of the α-chain of GPIb (GPIbα). Results—Genotypes with 145Met (T/M and M/M) were more frequently found in the CVD patients (26.5%) than in control subjects (14.2%, P=0.0005). The genotype effect was more obvious in those <60 years of age or without acquired cardiovascular risk factors. The odds ratio for nonsmoking women...