Effect of mannitol on intracranial pressure-volume status and cerebral haemodynamics in brain oedema.
Effect of mannitol on intracranial pressure-volume status and cerebral haemodynamics in brain oedema.
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甘露醇对脑水肿时颅内压-容量状态和脑血流动力学的影响。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
M. Furuse
中科院分区：
文献类型：
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作者：
S. Inao;H. Kuchiwaki;A. Wachi;K. Andoh;M. Nagasaka;K. Sugita;M. Furuse
采用激光多普勒血流仪连续测量脑血流量和脑血流量，分析脑水肿模型脑血管对水分积聚反应的时间分布。使用这种方法，还检测了甘露醇对脑血流量的影响，以确定甘露醇如何改善颅内压-容量关系。结果表明：(1)水肿源的存在引起脑血流量的持续减少和一过性脑血流量的减少。随着这种水肿性机械作用力的停止，脑血流量和脑血流量恢复到控制水平。(2)甘露醇可增加CBV和PVI。PVI的改善可能是由于CBV的增加和颅内压的降低所致。
Continuous measurement of CBV and CBF by means of laser-Doppler flowmetry was performed to analyze the temporal profile of cerebrovascular response to water accumulation in an infusion model of brain oedema. Using this method, the effect of mannitol on CBV was also examined to determine how mannitol improves the intracranial pressure-volume relationship. The results show that: (1) The presence of an oedema generator elicits a continuous reduction of CBV and a transient reduction of CBF. With cessation of this mechanical force of oedema production, CBV and CBF return to control levels. (2) Mannitol increases CBV and PVI. The improvement of PVI might be due to an increase in CBV as well as ICP reduction.