Circadian clocks and cell division What's the pacemaker?
Circadian clocks and cell division What's the pacemaker?
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DOI：
10.4161/cc.9.19.13205
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发表时间：
2010-10-01
期刊：
影响因子：
4.3
通讯作者：
Johnson, Carl Hirschie
中科院分区：
文献类型：
--
作者：
Johnson, Carl Hirschie
进化选择了两个相互交织的细胞周期系统：细胞分裂周期（CDC）和每日（昼夜）生物钟。生物钟跟踪太阳时间，并将生物过程编程为在环境适当的时间发生。其中一个过程是CDC，它通常由昼夜节律钟控制。这两个细胞周期的相互交织可能是观察到昼夜节律系统的破坏增加了对某些癌症的易感性的原因。昼夜节律时钟的核心机制被认为是转录和翻译反馈环（TTFL），但最近对蓝细菌，合成振荡器和永生细胞系的研究证据表明，在哺乳动物细胞中门控细胞分裂的核心昼夜节律起搏机制可能是翻译后振荡器（PTO）。
E volution has selected a system of two intertwined cell cycles: the cell division cycle (CDC) and the daily (circadian) biological clock. The circadian clock keeps track of solar time and programs biological processes to occur at environmentally appropriate times. One of these processes is the CDC, which is often gated by the circadian clock. The intermeshing of these two cell cycles is probably responsible for the observation that disruption of the circadian system enhances susceptibility to some kinds of cancer. The core mechanism underlying the circadian clockwork has been thought to be a transcription & translation feedback loop (TTFL), but recent evidence from studies with cyanobacteria, synthetic oscillators and immortalized cell lines suggests that the core circadian pacemaking mechanism that gates cell division in mammalian cells could be a post-translational oscillator (PTO).