An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen
An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen
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DOI：
10.1016/s0047-6374(00)00089-0
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发表时间：
2000-04-14
影响因子：
5.3
通讯作者：
Miquel, J
中科院分区：
文献类型：
--
作者：
Boscá, AR;Soler, A;Miquel, J
正如Pilgeram（1993年）所指出的，“人类历史上没有任何疾病比心脏或血管疾病造成的死亡率更高。“然而，这种疾病的病理生理机制尚未完全了解。追溯到1846年，Von Rokitansky是第一个提出纤维物质在动脉内皮壁上的积累是冠心病的根本原因的人（Von Rokitansky，1846），大约在同一时间，Anitschow（1933）表明高胆固醇和高脂肪的饮食导致动脉粥样硬化斑块的形成。根据Pilgeram（1993）的说法，这是目前两种动脉粥样硬化形成概念的起源：一种基于纤维组织的形成，另一种基于胆固醇的积累。他的结论是，这两种机制可能起协同作用，纤维形成血液蛋白纤维蛋白原可能的致动脉粥样硬化作用可能有助于上述机制的概念整合。他自己的数据表明，血浆纤维蛋白原水平随年龄增加而增加，这在动脉粥样硬化患者中更为显著。Stone和Thorp（1985）也为血浆纤维蛋白原是主要的冠状动脉危险因素这一观点提供了有力的支持。他们表明，在40-69岁的男性中，最初没有明显的冠心病，初始血浆纤维蛋白原水平与随后的心脏病发作发生率之间存在显着的正相关性。具体而言，在高胆固醇或高收缩压值的男性心脏病发作的频率是，分别为6倍和12倍，在那些高血浆纤维蛋白原水平比那些低纤维蛋白原水平。此外，这些作者指出：在多变量模型中，血浆纤维蛋白原是一个高度显著和独立的解释变量，至少与血清胆固醇、血压或吸烟一样重要。这些结果表明，高血浆纤维蛋白原水平是一个重要的必然危险因素，应包括在用于识别心脏病发作高危人群的资料中。'
As pointed out by Pilgeram (1993), 'no disease in the history of mankind exacts a greater toll in morbidity than heart or blood vessel disease.' However, the physiopathological mechanisms responsible for this disease are not fully understood. Dating back to 1846, Von Rokitansky was the first to propose that the accumulation of a fibrous substance on the endothelial wall of arteries is the fundamental cause of coronary heart disease (Von Rokitansky, 1846), and at about the same time Anitschow (1933) showed that diets high in cholesterol and fat result in the formation of atheromatous plaques. According to Pilgeram (1993), this was the origin of the two current concepts of atherogenesis: one based on the formation of fibrous tissue, the other on the accumulation of cholesterol. He concludes that the two mechanisms may act in synergy and that the probable atherogenic role of the fiber-forming blood protein fibrinogen may help in the conceptual integration of the above mechanisms. His own data showed an age-related increase in the plasma levels of fibrinogen which was more striking in atherosclerotic subjects, Strong support for the concept that plasma fibrinogen is a major coronary risk factor nad been also provided by Stone and Thorp (1985). They showed that in men aged 40-69 years, who were initially free from overt coronary heart disease, there was a significant positive correlation between initial plasma fibrinogen levels and the subsequent incidence of heart attacks. Specifically, in men with high cholesterol or high systolic blood pressure values the frequency of heart attacks was, respectively six and 12 times greater in those with high plasma fibrinogen levels than in those with low fibrinogen levels. Moreover, these authors state: 'In multivariate models plasma fibrinogen was a highly significant and independent explanatory variable, at least as important as serum cholesterol, blood presure or cigarette; smoking. These results suggest that high plasma fibrinogen levels ale an important corollary risk factor and should be included in profiles used to identify those at high risk of heart attacks.'