Oral exposure to polystyrene nanoparticles affects iron absorption
Oral exposure to polystyrene nanoparticles affects iron absorption
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DOI：
10.1038/nnano.2012.3
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发表时间：
2012-04-01
影响因子：
38.3
通讯作者：
Shuler, Michael L.
中科院分区：
文献类型：
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作者：
Mahler, Gretchen J.;Esch, Mandy B.;Shuler, Michael L.
工程纳米颗粒在食品和药品中的使用预计会增加，但长期口服纳米颗粒对人类健康的影响仍不清楚。在这里，我们表明，慢性和急性口服聚苯乙烯纳米粒子可以影响体外肠上皮模型和体内鸡肠环模型中的铁吸收和铁转运。暴露于高剂量纳米颗粒的肠细胞由于纳米颗粒破坏细胞膜而表现出铁转运增加。急性暴露于羧化颗粒（直径 50 nm）的鸡比未暴露或长期暴露的鸡具有较低的铁吸收率。长期接触会导致肠绒毛重塑，从而增加可用于铁吸收的表面积。体外和体内结果之间的一致性表明我们的体外肠上皮模型对于毒理学研究可能有用。
The use of engineered nanoparticles in food and pharmaceuticals is expected to increase, but the impact of chronic oral exposure to nanoparticles on human health remains unknown. Here, we show that chronic and acute oral exposure to polystyrene nanoparticles can influence iron uptake and iron transport in an in vitro model of the intestinal epithelium and an in vivo chicken intestinal loop model. Intestinal cells that are exposed to high doses of nanoparticles showed increased iron transport due to nanoparticle disruption of the cell membrane. Chickens acutely exposed to carboxylated particles (50 nm in diameter) had a lower iron absorption than unexposed or chronically exposed birds. Chronic exposure caused remodelling of the intestinal villi, which increased the surface area available for iron absorption. The agreement between the in vitro and in vivo results suggests that our in vitro intestinal epithelium model is potentially useful for toxicology studies.