Searching for the holy grail: temporally informative firing patterns in the rat.
Searching for the holy grail: temporally informative firing patterns in the rat.
复制标题
寻找圣杯：老鼠的暂时信息发射模式。
DOI：
10.1007/978-1-4939-1782-2_12
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发表时间：
2014
影响因子：
--
通讯作者：
Matell,MatthewS
中科院分区：
文献类型：
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作者：
Matell,MatthewS
本章回顾了我们在过去十年中研究大鼠皮层和纹状体放电模式的工作，同时它们的时间间隔在几秒范围内。我们发现，皮质和纹状体放电率都包含信息，大鼠可以利用这些信息来确定从试验开始和从主动反应状态开始经过的时间。我描述的研究结果表明，受时间调节的纹状体神经元也受到明显行为的调节，这表明时间调节纹状体中运动编码的强度，而不是孤立地表示为抽象量。我还描述了表明前运动皮层存在多种时间信息活动模式的研究，并认为这些模式的异质性可以增强生物体的时间估计。最后，我描述了我的实验室最近的行为工作，其中多个持续时间的同时提示导致中间时间的标量时间期望，为时间的单调表示提供了强有力的支持。
This chapter reviews our work from the past decade investigating cortical and striatal firing patterns in rats while they time intervals in the multi-seconds range. We have found that both cortical and striatal firing rates contain information that the rat can use to identify how much time has elapsed both from trial onset and from the onset of an active response state. I describe findings showing that the striatal neurons that are modulated by time are also modulated by overt behaviors, suggesting that time modulates the strength of motor coding in the striatum, rather than being represented as an abstract quantity in isolation. I also describe work showing that there are a variety of temporally informative activity patterns in pre-motor cortex, and argue that the heterogeneity of these patterns can enhance an organism’s temporal estimate. Finally, I describe recent behavioral work from my lab in which the simultaneous cueing of multiple durations leads to a scalar temporal expectation at an intermediate time, providing strong support for a monotonic representation of time.