High-definition transcranial direct current stimulation modulates performance and alpha/beta parieto-frontal connectivity serving fluid intelligence.
High-definition transcranial direct current stimulation modulates performance and alpha/beta parieto-frontal connectivity serving fluid intelligence.
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DOI：
10.1113/jp282387
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发表时间：
2021-12
影响因子：
5.5
通讯作者：
Wilson, Tony W.
中科院分区：
文献类型：
--
作者：
Arif, Yasra;Spooner, Rachel K.;Heinrichs-Graham, Elizabeth;Wilson, Tony W.
流体智能（Fluid Intelligence，GEOSS）包括逻辑推理能力，是规范认知的重要组成部分。尽管广泛的共识是顶叶-前额叶连接对Gf至关重要（例如，顶叶-额叶整合智力理论，P-FIT），这种功能连接在逻辑推理过程中的动态仍然知之甚少。此外，考虑到这些脑区对Gf的已知重要性，许多研究已经针对这些区域中的一个或两个区域进行非侵入性刺激，目的是改善Gf，但迄今为止，对整体刺激相关效应的共识仍然很少。为了检验这一点，我们应用高清晰度直流电阳极刺激的左，右背外侧前额叶皮层（DLPFC）的24名健康成人20分钟，在三个独立的会议（假，左，右活跃）。刺激后，参与者在脑磁图（MEG）中完成了一项逻辑推理任务。使用波束形成器对传感器水平的显著神经反应进行成像，并对峰值任务诱导的活动进行动态功能连接分析，以评估不同刺激蒙太奇对网络活动的影响。我们发现，与假手术相比，参与者在右侧DLPFC刺激后反应更快。此外，我们的神经研究结果遵循类似的影响轨迹，例如与假手术相比，右侧和左侧DLPFC刺激后左侧顶叶-额叶连接减少，右侧刺激后的连接与更快的反应时间显著相关。重要的是，我们的研究结果与P-FIT以及智力的神经效率假说（NEH）一致。总之，本研究为右侧DLPFC刺激对逻辑推理的有益影响提供了证据。离线前额叶HD-tDCS调制行为和网络水平的神经元活动的逻辑推理在健康成年人。右侧DLPFC刺激后反应时间改善，与假手术相比，这进一步与α/β范围内的左侧顶叶-额叶连接降低相关。
Fluid intelligence (Gƒ) includes logical reasoning abilities and is an essential component of normative cognition. Despite the broad consensus that parieto-prefrontal connectivity is critical for Gf (e.g., the parieto-frontal integration theory of intelligence, P-FIT), the dynamics of such functional connectivity during logical reasoning remains poorly understood. Further, given the known importance of these brain regions for Gf, numerous studies have targeted one or both of these areas with noninvasive stimulation with the goal of improving Gf, but to date there remains little consensus on the overall stimulation-related effects. To examine this, we applied high-definition direct current anodal stimulation to the left and right dorsolateral prefrontal cortex (DLPFC) of twenty-four healthy adults for 20 min in three separate sessions (sham, left and right active). Following stimulation, participants completed a logical reasoning task during magnetoencephalography (MEG). Significant neural responses at the sensor-level were imaged using a beamformer, and peak task-induced activity was subjected to dynamic functional connectivity analyses to evaluate the impact of distinct stimulation montages on network activity. We found that participants responded faster following right DLPFC stimulation versus sham. Moreover, our neural findings followed a similar trajectory of effects such that left parieto-frontal connectivity decreased following right and left DLPFC stimulation compared to sham, with connectivity following right stimulation being significantly correlated with the faster reaction times. Importantly, our findings are consistent with P-FIT, as well as the neural efficiency hypothesis (NEH) of intelligence. In sum, this study provides evidence for beneficial effects of right DLPFC stimulation on logical reasoning. Offline prefrontal HD-tDCS modulated behavioral and network-level neuronal activity underlying logical reasoning in healthy adults. The reaction time improved following right DLPFC stimulation, which was further associated with decreased left parieto-frontal connectivity in the alpha/beta range compared to sham.