Maternal myo-inositol, glucose, and zinc status is associated with the risk of offspring with spina bifida
Maternal myo-inositol, glucose, and zinc status is associated with the risk of offspring with spina bifida
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DOI：
10.1016/s0002-9378(03)00807-x
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发表时间：
2003-12-01
影响因子：
9.8
通讯作者：
Steegers-Theunissen, RP
中科院分区：
文献类型：
--
作者：
Groenen, PM;Peer, PG;Steegers-Theunissen, RP
目的：本研究的目的是调查母亲和儿童的肌醇，葡萄糖和锌的状态与脊柱裂risk.Study设计：63位母亲和70名儿童脊柱裂和102个对照母亲和85个对照儿童进行了调查。母亲和儿童血清肌醇，血糖和红细胞锌浓度测定时，孩子在1至3岁。这些数据在病例组和对照组之间进行了比较。与脊柱裂的关联表示的比率的几何平均数和比值比和95%CI的临界值在极端的第10百分位数的control group.Results：母亲的肌醇浓度的几何平均值往往是5%（95%CI，-1%至11%）的情况下，低。有趣的是，母体肌醇浓度极低的比值比为2.6（95% CI，1.1-6.0）。与对照组母亲相比，病例母亲的葡萄糖和锌浓度在7%（95%Cl，4%-10%）时显著较高，在5%（95%Cl，0%-9%）时显著较低。母体高血糖和低锌浓度的比值比（95%CI）分别为4.6（2.0-10.5）和2.9（1.2-7.0）。肌醇浓度的几何平均值往往是7%（95%CI，0%-14%）低脊柱裂的儿童;葡萄糖和锌的浓度是comparable.CONCLUSION：母亲肌醇，葡萄糖和锌的状态与脊柱裂的风险在后代。此外，儿童的肌醇状态似乎也有助于这种风险。(Am J Obstet Gynecol 2003;189：1713-9.）
OBJECTIVE: The purpose of this study was to investigate the maternal and children's myo-inositol, glucose, and zinc status in association with spina bifida risk.STUDY DESIGN: Sixty-three mothers and 70 children with spina bifida and 102 control mothers and 85 control children were investigated. The maternal and child serum myo-inositol, serum glucose, and red blood cell zinc concentrations were measured when the child was between 1 and 3 years old. These data were compared between cases and control subjects. The association with spina bifida was expressed by the ratio of geometric means and by odds ratios and 95% Cl for a cutoff value at the extreme 10th percentile of the control group.RESULTS: The geometric mean of the maternal myo-inositol concentration tended to be 5% (95% CI, -1% to 11%) lower in cases. Interestingly, the odds ratio for the extreme low maternal myo-inositol concentration was 2.6 (95% Cl, 1.1-6.0). The glucose and zinc concentrations were significantly higher at 7% (95% Cl, 4%-10%) and significantly lower at 5% (95% Cl, 0%-9%), in case mothers compared with control mothers. The odds ratios (95% CI) for maternal high glucose and low zinc concentrations were 4.6 (2.0-10.5) and 2.9 (1.2-7.0), respectively. The geometric mean of the myo-inositol concentration tended to be 7% (95% Cl, 0%-14%) lower in children with spina bifida; the glucose and zinc concentrations were comparable.CONCLUSION: Maternal myo-inositol, glucose, and zinc status are associated with the risk of spina bifida in offspring. Furthermore, the myo-inositol status of the child seems to contribute to this risk as well. (Am J Obstet Gynecol 2003;189:1713-9.)