Enhanced intersubject correlations during movie viewing correlate with successful episodic encoding
Enhanced intersubject correlations during movie viewing correlate with successful episodic encoding
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DOI：
10.1016/j.neuron.2007.12.009
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发表时间：
2008-02-07
期刊：
影响因子：
16.2
通讯作者：
Davachi, Lila
中科院分区：
文献类型：
--
作者：
Hasson, Uri;Furman, Orit;Davachi, Lila
虽然已经了解了很多关于支持情节编码的神经基板使用高度控制的实验协议，相对较少的是已知的关于现实世界的事件的情节编码的神经基础。为了研究这个问题，我们在观察者观看一部新的电视情景喜剧时测量了fMRI活动。三周后，随后的记忆（SM）的电影事件的叙事内容进行了评估。我们基于受试者的后续记忆（ISC-SM）表现分析了受试者间相关性（ISC）的编码数据，以识别在成功编码的电影部分期间与未成功编码相比，BOLD响应在受试者之间显著更相关的大脑区域。这些区域包括海马旁回、上级颞回、前颞极和颞顶交界处。进一步的分析表明：（1）这些相关区域可以显示不同的激活曲线，（2）ISC-SM分析的结果与更传统的线性模型互补，并允许分析复杂的时间过程数据。因此，ISC-SM分析扩展了传统的后续记忆的研究结果，丰富的，动态的和更生态有效的情况。
While much has been learned regarding the neural substrates supporting episodic encoding using highly controlled experimental protocols, relatively little is known regarding the neural bases of episodic encoding of real-world events. In an effort to examine this issue, we measured fMRI activity while observers viewed a novel TV sitcom. Three weeks later, subsequent memory (SM) for the narrative content of movie events was assessed. We analyzed the encoding data for intersubject correlations (ISC) based on subjects' subsequent memory (ISC-SM) performance to identify brain regions whose BOLD response is significantly more correlated across subjects during portions of the movie that are successfully as compared to unsuccessfully encoded. These regions include the parahippocampal gyrus, superior temporal gyrus, anterior temporal poles, and the temporal-parietal junction. Further analyses reveal (1) that these correlated regions can display distinct activation profiles and (2) that the results seen with the ISC-SM analysis are complementary to more traditional linear models and allow analysis of complex time course data. Thus, the ISC-SM analysis extends traditional subsequent memory findings to a rich, dynamic and more ecologically valid situation.