Contribution of bacterial superantigens to atopic dermatitis
Contribution of bacterial superantigens to atopic dermatitis
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DOI：
10.1159/000024085
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发表时间：
1999-02-01
影响因子：
2.8
通讯作者：
Renz, H
中科院分区：
文献类型：
--
作者：
Herz, U;Bunikowski, R;Renz, H
结论 T细胞激活和IgE产生在AD的免疫发病机制中发挥着重要作用。细菌超抗原已被鉴定为与这两个事件相互作用的有效蛋白质。它们触发局部 T 细胞积累和针对超级抗原的 IgE 产生。因此，超抗原被认为是 AD 中重要的免疫激活剂。
ConclusionBoth, T–cell activation and IgE production play an important role in the immunopathogenesis of AD. Bacterial superantigens have been identified as potent proteins that interact with both of these events. They trigger local T–cell accumulation and IgE production against superantigens. Thus, superantigens are considered important immune activators in AD.