Pharmacotherapy improves treatment outcome in depressed cocaine addicts.
Pharmacotherapy improves treatment outcome in depressed cocaine addicts.
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药物治疗可改善抑郁可卡因成瘾者的治疗结果。
DOI：
10.1080/02791072.1991.10471612
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发表时间：
1991
影响因子：
2.8
通讯作者：
Kosten,TR
中科院分区：
文献类型：
--
作者：
Ziedonis,DM;Kosten,TR
抑郁症是物质滥用者最常见的精神障碍，导致预后较差，对传统的化学依赖和心理健康治疗方法的反应较差。本文着重介绍药物疗法在可卡因成瘾者继发性抑郁治疗中的应用，并提供一般的临床治疗指南。它还报道了一项关于抑郁症的研究。在一项为期12周的安慰剂对照试验中，美沙酮维持的可卡因成瘾者接受了治疗，比较了两种药物。患者被随机分配接受安慰剂、金刚烷胺(一种多巴胺激动剂)或地塞帕明(一种三环类抗抑郁药)。评估药物治疗对程序保持、可卡因渴求、可卡因使用和抑郁情绪的影响。与接受安慰剂治疗的患者相比，研究发现，接受药物治疗的抑郁症患者报告的可卡因使用量(84%比17%)和对可卡因的渴望(48%比29%增加)大幅减少。此外，与接受安慰剂治疗的抑郁症患者相比，接受药物治疗的抑郁症患者的无可卡因尿液百分比显著增加，后者实际上降低了他们的无可卡因尿液百分比。接受安慰剂治疗的抑郁症患者的抑郁症状指标(贝克抑郁指数评分)增加了100%，而接受药物治疗的抑郁症患者保持稳定。
Depression is the most common psychiatric disorder in substance abusers, and results in a poorer prognosis and respons e to traditional chemical dependence and mental health treatment approaches. This article focuses on the use of pharmacotherapy in the treatment of the cocaine addict with secondary depression and provides general clinical treatment guidelines. It also reports on a study in which depressed. methadonemaintained cocaine addicts were treated in a 12-week placebo-controlled trial that compared two pharmacological agents. Patients were randomly assigned to receive placebo, amantadine (a dopamine agonist) or desipramine (a tricyclic antidepressant). The effects of pharmacotherapy were assessed on program retention, cocaine craving, cocaine usage, and depressed mood. Compared to the placebo-treated patients, it was found that the medication-treated depressed patients had a dramatic decrease in their reported cocaine usage (84% versus 17%) and cocaine craving (48% decrease versus 29% increase). Also, the medication-treated depressed patients dramatically increased the percentage of cocaine-free urines compared to the placebo-treated depressed patients who actually decreased their percentage of cocaine-free urines. A measure of depressive symptoms (Beck Depression Index score) increased 100% for the placebo-treated depressed patients, yet remained stable for the medication-treated depressed patients.
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影响因子：
2.7
作者：
CARROLL, KM;ROUNSAVILLE, BJ;KELLER, DS
通讯作者：
KELLER, DS
溴隐亭治疗可卡因滥用
DOI：
10.1016/s0140-6736(85)92448-1
发表时间：
1985
期刊：
The Lancet
影响因子：
--
作者：
C. Dackis;M. Gold
通讯作者：
M. Gold
影响因子：
--
作者：
D. Charney;D. Menkes;G. Heninger
通讯作者：
D. Charney;D. Menkes;G. Heninger
寻求治疗的可卡因滥用者的精神病学诊断。
影响因子：
--
作者：
Rounsaville,BJ;Anton,SF;Carroll,K;Budde,D;Prusoff,BA;Gawin,F
通讯作者：
Gawin,F
针对低收入和少数族裔患者的有效心理治疗
DOI：
--
发表时间：
1982
期刊：
影响因子：
--
作者：
F. X. Acosta;J. Yamamoto;L. Evans;S. Wilcox
通讯作者：
S. Wilcox