Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages.
Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages.
复制标题
人类大脑主要发育阶段的性别偏见基因表达谱
DOI：
10.1038/srep21181
复制
发表时间：
2016-02-16
影响因子：
4.6
通讯作者：
Su B
中科院分区：
文献类型：
--
作者：
Shi L;Zhang Z;Su B
男性和女性的大脑结构和功能有很多不同。然而，这些差异如何在发育过程中表现出来，并在成年期保持不变，目前尚不清楚。在这里，我们提出了一个时间序列分析的全基因组的人类大脑的转录谱，我们确定了基因显示性别偏见的表达在主要的发展阶段（产前时间，幼儿期，青春期和成年期）。我们观察到大量的基因（> 2，000个基因）在所有发育阶段都表现出性别间表达差异，其中青春期的基因数量最多（4，164个基因）。然而，在主要的发育阶段中，性别偏向基因几乎没有重叠，这表明在发育过程中，性别偏向基因在大脑中的动态表达调控。值得注意的是，男性偏好基因高度富集了涉及神经和精神疾病的基因，如精神分裂症，双相情感障碍，阿尔茨海默病和自闭症，而女性偏好基因则没有这种模式，这表明男性和女性之间大脑疾病易感性的差异可能源于大脑发育过程中的性别偏好基因表达调控。总的来说，这些分析揭示了性别偏见基因在大脑发育和神经发育障碍中的重要作用。
There are many differences in brain structure and function between males and females. However, how these differences were manifested during development and maintained through adulthood are still unclear. Here we present a time series analyses of genome-wide transcription profiles of the human brain, and we identified genes showing sex biased expression at major developmental stages (prenatal time, early childhood, puberty time and adulthood). We observed a great number of genes (>2,000 genes) showing between-sex expression divergence at all developmental stages with the greatest number (4,164 genes) at puberty time. However, there are little overlap of sex-biased genes among the major developmental stages, an indication of dynamic expression regulation of the sex-biased genes in the brain during development. Notably, the male biased genes are highly enriched for genes involved in neurological and psychiatric disorders like schizophrenia, bipolar disorder, Alzheimer’s disease and autism, while no such pattern was seen for the female-biased genes, suggesting that the differences in brain disorder susceptibility between males and females are likely rooted from the sex-biased gene expression regulation during brain development. Collectively, these analyses reveal an important role of sex biased genes in brain development and neurodevelopmental disorders.