Influence of a newly developed quinolone, T-3761, on pharmacokinetics of theophylline in rats
Influence of a newly developed quinolone, T-3761, on pharmacokinetics of theophylline in rats
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新开发的喹诺酮类药物 T-3761 对大鼠茶碱药代动力学的影响
DOI：
10.1128/aac.39.9.2138
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发表时间：
1995
影响因子：
4.9
通讯作者：
Toshitaka Nabeshima
中科院分区：
文献类型：
--
作者：
Tatsuya Hasegawa;M. Nadai;S. Haghgoo;Kenichi Yamaki;K. Takagi;Toshitaka Nabeshima
研究了新喹诺酮类药物T-3761对茶碱在大鼠体内药动学和代谢的影响。在静脉注射茶碱（10 mg/kg）前10分钟静脉注射高剂量（20 mg/kg体重）T-3761。T-3761的存在略微延迟了茶碱从血浆中的消失。通过非房室方法估计茶碱和T-3761之间的药代动力学相互作用相关参数。在存在T-3761的情况下，观察到茶碱的全身清除率显著降低（约25%）。然而，对照组和T-3761给药组之间未观察到稳态分布容积的显著变化。T-3761预处理增加了原型茶碱的尿排泄（约25%），并降低了非肾清除率（约30%），表明T-3761抑制了茶碱的代谢。这些结果表明，在本研究中使用的剂量下，T-3761影响茶碱的药代动力学和代谢。
The effect of a new quinolone, T-3761, on the pharmacokinetics and metabolism of theophylline was investigated with rats. T-3761 at a high dose (20 mg/kg of body weight) was injected intravenously 10 min before an intravenous administration of theophylline (10 mg/kg). The presence of T-3761 slightly delayed the disappearance of theophylline from plasma. Parameters related to the pharmacokinetic interaction between theophylline and T-3761 were estimated by noncompartmental methods. A significant decrease (approximately 25%) in the systemic clearance of theophylline was observed in the presence of T-3761. However, no significant changes between the control group and the T-3761-treated groups in the volume of distribution at a steady state were observed. Pretreatment with T-3761 increased the urinary excretion of unchanged theophylline (by approximately 25%) and decreased the nonrenal clearances (by approximately 30%), indicating that T-3761 inhibits the metabolism of theophylline. These findings suggest that T-3761 at the dose used in this study affects the pharmacokinetics and metabolism of theophylline.