Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium.
Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium.
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DOI：
10.1177/1534735403261831
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发表时间：
2004-03-01
影响因子：
2.9
通讯作者：
Finley, John W
中科院分区：
文献类型：
--
作者：
Keck, Anna-Sigrid;Finley, John W
饮食专家敦促美国人增加水果和蔬菜的摄入量。美国癌症研究所估计，如果唯一的饮食改变是将每天水果和蔬菜的摄入量增加到每天5份，癌症发病率可能会下降多达20%。对健康有益的理由之一是水果和蔬菜是纤维、维生素和矿物质的极好来源。它们还含有非营养成分，除了基本营养外，还可能提供实质性的健康益处。后者的例子有硫代葡萄糖苷水解物、萝卜硫烷和吲哚-3-甲醇。流行病学研究提供的证据表明，食用十字花科蔬菜比摄入全部水果和蔬菜更有效地预防癌症。本文综述了硫代葡萄糖苷水解物的抗癌生物活性、十字花科植物中提取的矿物质硒及其抗癌机制。这些机制包括雌激素代谢的改变、对活性氧的保护、通过诱导II相酶来改变解毒作用、通过抑制I相酶来降低致癌物的活性、减缓肿瘤的生长和诱导细胞凋亡。
Dietetic professionals urge Americans to increase fruit and vegetable intakes. The American Institute of Cancer Research estimates that if the only dietary change made was to increase the daily intake of fruits and vegetables to 5 servings per day, cancer rates could decline by as much as 20%. Among the reasons cited for this health benefit are that fruits and vegetables are excellent sources of fiber, vitamins, and minerals. They also contain nonnutritive components that may provide substantial health benefits beyond basic nutrition. Examples of the latter are the glucosinolate hydrolysis products, sulforaphane, and indole-3-carbinol. Epidemiological studies provide evidence that the consumption of cruciferous vegetables protects against cancer more effectively than the total intake of fruits and vegetables. This review describes the anticarcinogenic bioactivities of glucosinolate hydrolysis products, the mineral selenium derived from crucifers, and the mechanisms by which they protect against cancer. These mechanisms include altered estrogen metabolism, protection against reactive oxygen species, altered detoxification by induction of phase II enzymes, decreased carcinogen activation by inhibition of phase I enzymes, and slowed tumor growth and induction of apoptosis.