Increased interleukin-8 and monocyte chemoattractant protein-1 concentrations in mechanically ventilated preterm infants with pulmonary hemorrhage
Increased interleukin-8 and monocyte chemoattractant protein-1 concentrations in mechanically ventilated preterm infants with pulmonary hemorrhage
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DOI：
10.1002/ppul.10141
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发表时间：
2002-08-01
影响因子：
3.1
通讯作者：
Kruger, TE
中科院分区：
文献类型：
--
作者：
Baier, RJ;Loggins, J;Kruger, TE
肺出血（PH）是早产儿急性呼吸窘迫的严重并发症，其病死率和致残率都很高。炎症介质在这种情况下的作用在很大程度上是不确定的。在出生后21天内，对65名出生体重小于1,250 g的机械通气婴儿进行连续气管抽吸（TA）。15名婴儿出现临床显著PH。采用酶联免疫吸附试验（ELISA）测定TA中白细胞介素-8（IL-8）和单核细胞趋化蛋白-1（MCP-1）的浓度。PH与死亡、支气管肺发育不良、脑室内出血和长期需要机械通气和补充氧气的风险增加相关。与未发生PH的婴儿相比，PH婴儿的TA抽吸物中IL-8和MCP-1的浓度（P = 0.001，ANOVA）显著增加。TA细胞因子浓度也显着增加的婴儿谁发展支气管肺发育不良（BPD）。IL-8和MCP-1的TA峰值浓度在预后不良（BPD或死亡）的婴儿中显著较高。TA MCP-1而非IL-8浓度在孕后36周时依赖氧的婴儿中显著更高。这些数据表明IL-8和MCP-1在具有临床显著PH的早产儿的不良肺结果的发展中的致病作用。
Pulmonary hemorrhage (PH) is a serious complication causing acute respiratory distress in the premature infant, and it is associated with significant mortality and morbidity. The role of inflammatory mediators in this condition is largely undefined. Serial tracheal aspirates (TA) were obtained at intervals from 65 mechanically ventilated infants with birth weights less than 1,250 g during the first 21 days of life. Clinically significant PH developed in 15 infants. TA concentrations of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) were determined by enzyme-linked immunosorbent assay (ELISA).PH was associated with an increased risk of death, bronchopulmonary dysplasia, intraventricular hemorrhage, and prolonged need for mechanical ventilation and supplemental oxygen. TA aspirate concentrations of IL-8 and MCP-1 (P = 0.001, ANOVA) were significantly increased in infants with PH compared to infants who did not develop this condition. TA cytokine concentrations were also significantly increased in infants who developed bronchopulmonary dysplasia (BPD). Peak TA concentrations of IL-8 and MCP-1 were significantly higher in infants with poor outcome (BPD or death). TA MCP-1 but not IL-8 concentrations were significantly higher in infants who were oxygen-dependent at 36 weeks postconceptional age.These data suggest a pathogenic role for IL-8 and MCP-1 in the development of adverse pulmonary outcome in preterm infants with clinically significant PH. (C) 2002 Wiley-Liss Inc.