Effects of the APOE ε2 allele on mortality and cognitive function in the oldest old.
Effects of the APOE ε2 allele on mortality and cognitive function in the oldest old.
复制标题
APOE ε2 等位基因对老年人死亡率和认知功能的影响。
DOI：
--
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
L. Christiansen
中科院分区：
文献类型：
--
作者：
R. Lindahl;Q. Tan;J. Mengel;K. Christensen;A. Nebel;L. Christiansen
一些研究表明 APOE ε2 等位基因可能对老年人的死亡率和心理健康具有保护作用。我们调查了 APOE ε2 等位基因对 1651 名丹麦 1905 年出生队列成员的认知功能和死亡率的影响，这些成员实际上已经灭绝。我们发现与 APOE ε3 等位基因相比，APOE ε2 等位基因对死亡率没有保护作用。点估计表明，随着时间的推移，携带 APOE ε2 等位基因的人对认知能力下降的保护作用增强。认知评分并没有显着改变各种 APOE 基因型的死亡风险。我们没有发现 APOE ε2 等位基因对高龄老年人的死亡率有保护作用，但与我们之前的发现一致，我们发现 APOE ε4 携带者的死亡风险增加了 22%。 APOE ε2 等位基因可能对老年人的认知能力下降有保护作用。
Some studies indicate that the APOE ε2 allele may have a protective effect on mortality and mental health among the elderly adults. We investigated the effect of the APOE ε2 allele on cognitive function and mortality in 1651 members of the virtually extinct Danish 1905 birth cohort. We found no protective effect of the APOE ε2 allele on mortality compared with the APOE ε3 allele. The point estimates indicated an increased protection against cognitive decline over time for persons with the APOE ε2 allele. Cognitive score did not significantly modify the mortality risk of the various APOE genotypes. We did not find a protective effect of the APOE ε2 allele on mortality among the oldest old, but in agreement with our previous findings, we found a 22% increased mortality risk for APOE ε4 carriers. The APOE ε2 allele may be protective on cognitive decline among the oldest old.