Transcriptional mechanisms regulating Ca(2+) homeostasis.
Transcriptional mechanisms regulating Ca(2+) homeostasis.
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DOI：
10.1016/j.ceca.2010.10.001
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发表时间：
2011-05
期刊：
影响因子：
4
通讯作者：
Soboloff J
中科院分区：
文献类型：
--
作者：
Ritchie MF;Zhou Y;Soboloff J
Ca2+是一种动态的细胞次级信使，介导了大量的细胞反应。对这些过程的控制是通过泵和通道的广泛组合来实现的，这些泵和通道不仅可以调节细胞质内的Ca2+浓度，还可以调节所有细胞内的区室。这些泵和通道究竟是如何调控的，目前还不完全清楚，然而，最近的研究已经确定了锌指转录因子的早期生长反应（EGR）家族成员在这一过程中起着关键作用。其他几个转录因子在Ca2+稳态控制中的作用也得到了证实，包括Wilms肿瘤抑制因子1 （WT1）、活化T细胞核因子（NFAT）和c-myc。在这篇综述中，我们不仅将讨论这些转录因子如何调节参与Ca2+稳态控制的主要蛋白的表达，而且还将讨论Ca2+稳态的转录重塑如何影响Ca2+动力学和细胞反应。
Ca2+ is a dynamic cellular secondary messenger which mediates a vast array of cellular responses. Control over these processes is achieved via an extensive combination of pumps and channels which regulate the concentration of Ca2+ within not only the cytosol but also all intracellular compartments. Precisely how these pumps and channels are regulated is only partially understood, however, recent investigations have identified members of the Early Growth Response (EGR) family of zinc finger transcription factors as critical players in this process. The roles of several other transcription factors in control of Ca2+ homeostasis have also been demonstrated, including Wilms Tumor Suppressor 1 (WT1), Nuclear Factor of Activated T cells (NFAT) and c-myc. In this review, we will discuss not only how these transcription factors regulate the expression of the major proteins involved in control of Ca2+ homeostasis, but also how this transcriptional remodeling of Ca2+ homeostasis affects Ca2+ dynamics and cellular responses.
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