A CASE-CONTROL STUDY OF PARKINSONS-DISEASE IN A HORTICULTURAL REGION OF BRITISH-COLUMBIA
A CASE-CONTROL STUDY OF PARKINSONS-DISEASE IN A HORTICULTURAL REGION OF BRITISH-COLUMBIA
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DOI：
10.1002/mds.870090111
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发表时间：
1994-01-01
影响因子：
8.6
通讯作者：
CALNE, D
中科院分区：
文献类型：
--
作者：
HERTZMAN, C;WIENS, M;CALNE, D
我们比较了127例病例和245例对照的个人病史，以确定可能的环境危险因素，特发性帕金森病（IP）。在我们的对照组中，121人患有心脏病（CD），124人从选举名单（选民）中随机选择。使用逻辑回归并调整性别和年龄，我们进行了单独的分析：IP与CD和IP与选民。收集了完整的职业史，如已知的与农业果树部门相关的所有农药接触。我们发现IP和有一个职业，其中通过处理或直接接触农药接触是可能的，但没有特定的化学品与IP之间的显着关联。我们的结论是，虽然涉及使用农药的职业可能易患IP的发展，它似乎是可能的发病机制是多因素的，而不是一个特定的代理。
We compared personal histories of 127 cases and 245 controls to identify possible environmental risk factors for idiopathic parkinsonism (IP). Of our controls, 121 had cardiac disease (CD) and 124 were randomly selected from electoral lists (voters). Using logistic regression and adjusting for sex and age, we ran separate analyses: IP versus CD and IP versus voters. A full occupational history was collected, as was known contact with all pesticides associated with the tree fruit sector of the agricultural industry. We found a significant association between IP and having had an occupation in which exposure through handling or directly contacting pesticides was probable, but no specific chemicals were associated with IP. We conclude that although occupations involving the use of agricultural chemicals may predispose to the development of IP, it seems likely that the pathogenesis is multifactorial rather than related to a specific agent.