Controlled drug delivery of ciprofloxacin from ultrasonic hydrogel
Controlled drug delivery of ciprofloxacin from ultrasonic hydrogel
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DOI：
10.1515/epoly-2017-0123
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发表时间：
2018-03-01
期刊：
影响因子：
3.7
通讯作者：
Salavaty, Molod
中科院分区：
文献类型：
--
作者：
Ebrahimi, Rajabali;Salavaty, Molod
环丙沙星是一种抗菌氟喹诺酮类药物，在进入细菌细胞后阻止DNA合成。该药用于治疗细菌感染，以及用于治疗妇女尿路感染、感染性腹泻和伤寒的抗生素。本研究的目的是研究超声法制备的水凝胶对环丙沙星的控释作用。为此，首先对水凝胶的溶胀性能进行了评价，然后对药物的吸收进行了评价。膨胀后的水凝胶在50℃的烘箱中干燥，准备进行释放实验。在释放过程中，将装载的水凝胶粉末加入pH 7.4的缓冲溶液中，与人体条件相似。然后用紫外-可见分光光度计和校准曲线测定药物浓度。结果表明，该水凝胶对pH值敏感，是环丙沙星肠内给药的理想选择。此外，药物的吸收与载药过程中水凝胶的溶胀量和药物浓度成正比。利用傅里叶变换红外、紫外-可见、扫描电镜和热重分析光谱对水凝胶和载药的化学结构和形态进行了表征。根据本文的研究结果，丙烯酸基水凝胶可用于生物医学领域，特别是药物控释。
Ciprofloxacin is an antibacterial fluoroquinolone that stops the DNA synthesis, after penetration into the bacterial cells. This drug is applied in the curing of bacterial infections, as well as in antibiotics to treat urinary infections in women, infectious diarrhea and typhoid fever. The objective of the present work is to study controlled release of ciprofloxacin by hydrogel prepared by ultrasound. For this, first the swelling properties of hydrogel and then the absorption of drug were evaluated. The swollen hydrogel was dried in oven (50 degrees C) and was ready for release experiments. During release, the loaded powder of the hydrogel was added to a buffer solution of pH 7.4, similar to human body condition. Then drug concentration was measured using a UV-visible (UV-Vis) spectrophotometer and a calibration curve. The results showed that the hydrogel is sensitive to pH, which makes it a good candidate for ciprofloxacin delivery in intestine. In addition, it was shown that the drug absorption is proportional with the swelling content of the hydrogel and the drug concentration in the loading process. The chemical structure and morphology of the hydrogels and loaded drug were characterized using Fourier transform infrared, UV-Vis, scanning electronic microscopy and thermal gravimetric analysis spectroscopy. According to the results presented here, acrylic-based hydrogels can be used in biomedical fields, especially for controlled drug release.