Environmental explanation of prostate cancer progression based on the comprehensive analysis of perfluorinated compounds.
Environmental explanation of prostate cancer progression based on the comprehensive analysis of perfluorinated compounds.
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DOI：
10.1016/j.ecoenv.2023.115267
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发表时间：
2023-07
影响因子：
6.8
通讯作者：
Yuan Wei;Haibing He;Tian Han;Baozun Wang;Peng Ji;Xiang-Gen Wu;J. Qian;P. Shao
中科院分区：
文献类型：
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作者：
Yuan Wei;Haibing He;Tian Han;Baozun Wang;Peng Ji;Xiang-Gen Wu;J. Qian;P. Shao
全氟化合物（PFC）是一种人造化学品，用于制造具有防水和防污性能的许多产品。许多疾病已被证实与PFCs的暴露有关，包括乳腺纤维腺瘤、肝细胞癌、乳腺癌和睾丸间质细胞腺瘤。然而，PFCs是否促进前列腺癌的进展仍不清楚。本研究通过比较毒理基因组学数据库（CTD）、基因表达综合数据库（GEO）和癌症基因组图谱（TCGA）数据库，通过全面的生物信息学分析，发现了前列腺癌与五种PFC之间的相关性。此外，进一步的分析表明，几个PFC相关基因对前列腺癌患者表现出很强的预后价值。生存分析和受试者工作特征（ROC）曲线显示，基于PFC相关基因的预后模型对前列腺癌的预后具有很高的预测价值，有望成为未来前列腺癌的独立危险因素。体外实验证实了全氟辛酸（PFOA）和全氟壬酸（PFNA）对前列腺癌细胞生长的促进作用。这项研究为理解PFCs在前列腺癌中的作用提供了新的见解，并引起了人们对环境与癌症风险和进展的关注。
Perfluorinated compounds (PFCs) are man-made chemicals used in the manufacture of many products with water and dirt repellent properties. Many diseases have been proved to be related to the exposure of PFCs, including breast fibroadenoma, hepatocellular carcinoma, breast cancer and leydig cell adenoma. However, whether the PFCs promote the progression of prostate cancer remains unclear. In this work, through comprehensive bioinformatics analysis, we discovered the correlation between the prostate cancer and five PFCs using Comparative Toxicogenomics Database (CTD), Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. In addition, further analysis showed that several PFCs-related genes demonstrated strong prognostic value for prostate cancer patients. The survival analysis and receiver operating characteristic (ROC) curves revealed that PFCs-related genes based prognostic model held great predictive value for the prognosis of prostate cancer, which could potentially serve as an independent risk factor in the future. In vitro experiments verified the promotive role of perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) in the growth of prostate cancer cells. This study provided novel insights into understanding the role of PFCs in prostate cancer and brought attention to the environmental association with cancer risks and progression.