Cytochrome c promoter activity in soleus and white vastus lateralis muscles in rats.
Cytochrome c promoter activity in soleus and white vastus lateralis muscles in rats.
复制标题
大鼠比目鱼肌和白股外侧肌中细胞色素 c 启动子的活性。
DOI：
10.1152/jappl.1998.85.3.973
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Booth,FW
中科院分区：
文献类型：
--
作者：
Yan,Z;Booth,FW
Cytochromecprotein and mRNA are 300 and 100% higher, respectively, in the soleus muscle (predominantly slow-twitch oxidative) than the white vastus lateralis (predominately fast-twitch glycolytic) muscle (W. W. Winder, K. M. Baldwin, and J. O. Holloszy.Eur. J. Biochem.47: 461–467, 1974; M. M. Lai and F. W. Booth.J. Appl. Physiol.69: 843–848, 1990). However, the mechanisms controlling these differences in cytochromecmRNA are largely unknown. The present study employed direct plasmid injection techniques to determine whether the proximal promoter (−726 to +610) of the rat somatic cytochromecgene was more active in the soleus than in white vastus lateralis muscles in rats. No difference between the soleus and white vastus lateralis muscles for the activities of the −726, −631, −489, −326, −215, −159 and −149 cytochromecpromoters was noted. The results of this study suggest that additional elements (outside of −726 to +610) in the cytochromecgene may be required, or posttranscriptional regulation may account, for the higher cytochromecmRNA in the slow-twitch oxidative muscle.
