LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION AND HOUSE MOUSE (MUS-MUSCULUS) DISTRIBUTION IN URBAN BALTIMORE
LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION AND HOUSE MOUSE (MUS-MUSCULUS) DISTRIBUTION IN URBAN BALTIMORE
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DOI：
10.4269/ajtmh.1992.47.27
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发表时间：
1992-07-01
影响因子：
3.3
通讯作者：
LEDUC, JW
中科院分区：
文献类型：
--
作者：
CHILDS, JE;GLASS, GE;LEDUC, JW
从1984年到1989年，在马里兰州的巴尔的摩，主要从市区捕获了480只家鼠（Mus musculus），并检测了淋巴细胞性脉络丛脑膜炎病毒（LCMV）的抗体。大多数小鼠（95%）被困在两个城市位置的住宅（n = 260），或在城市公园（n = 196）;五个额外的网站进行了采样。总体而言，9.0%的小鼠为LCMV抗体阳性，感染动物来自8个地点中的6个，包括所有3个主要城市地点，其患病率差异显著（3.9-13.4%）。流行率最高的地点是内城居民区，在那里发现阳性小鼠明显聚集在街区和家庭内。在这个位置，LCMV抗体流行率也显着相关的估计个别街区内的小鼠密度。家鼠中LCMV感染的局灶性可能是由于病毒的接触或垂直传播以及小鼠高度结构化的社会系统，这促进了近亲繁殖和有限的传播。
Four hundred eighty house mice (Mus musculus) were trapped primarily from urban sites in Baltimore, Maryland from 1984 to 1989 and tested for antibody to lymphocytic choriomeningitis virus (LCMV). The majority of mice (95%) were trapped in residences at two city locations (n = 260), or in an urban park (n = 196); five additional sites were sampled. Overall, 9.0% of the mice were LCMV antibody positive and infected animals were obtained from six of eight sites, including all three of the primary city sites, where the prevalence varied significantly (3.9-13.4%). The location with the highest prevalence was an inner city residential site where positive mice were found significantly clustered within blocks and households. In this location, LCMV antibody prevalence was also significantly correlated with estimates of mouse density within individual blocks. The focal nature of LCMV infection in house mice may result from contact or vertical transmission of virus in conjunction with the highly structured social system of mice, which promotes inbreeding and limited dispersal.