Second primary lung cancer after head and neck squamous cell cancer: Population-based study of risk factors
Second primary lung cancer after head and neck squamous cell cancer: Population-based study of risk factors
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DOI：
10.1002/hed.22006
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发表时间：
2012-12-01
影响因子：
2.9
通讯作者：
Chen, Yuhchyau
中科院分区：
文献类型：
--
作者：
Milano, Michael T.;Peterson, Carl R., III;Chen, Yuhchyau
头颈部鳞状细胞癌（HNSCC）患者有发生第二原发性肺癌（SPLC）的风险。方法在来自监测、流行病学和最终结果（SEER）数据库的61，883例HNSCC患者中，4522例在HNSCC后2个月内发生SPLC（任何组织学）。我们将风险与人口统计学和肿瘤相关参数相关联。结果HNSCC术后5年、10年和15年发生SPLC的风险分别为5.8%、11.4%和16.4%。根据考克斯回归分析，SPLC的显著不良（p <0.0001）风险因素包括：区域性与局限性HNSCC分期（风险比[HR] = 1.16）、下咽或声门上喉部位（HR = 1.57）、年龄增加（HR = 1.26/10年）、黑人（HR = 1.27）和男性（HR = 1.26）。声门（HR = 0.75）和扁桃体或口腔部位（HR = 0.80）与SPLC风险显著降低（p <0.0001）相关。结论从人群统计学分析来看，临床病理特征更具侵袭性的HNSCC更容易发生SPLC，提示这些肿瘤的环境和/或宿主因素相似。(c)2012 Wiley Periodicals，Inc.头颈部，2012年
Background Patients with head and neck squamous cell cancer (HNSCC) are at risk of developing second primary lung cancer (SPLC). Methods Among 61,883 patients with HNSCC from the Surveillance, Epidemiology and End Results (SEER) database, 4522 developed SPLC (any histology) =2 months after HNSCC. We correlated risk with demographic and tumor-related parameters. Results The risk of SPLC after HNSCC was 5.8%, 11.4%, and 16.4% at 5, 10, and 15 years, respectively. From Cox regression, significantly adverse (p < .0001) risk factors for SPLC included: regional versus localized HNSCC stage (hazard ratio [HR] = 1.16), hypopharyngeal or supraglottic laryngeal site (HR = 1.57), increased age (HR = 1.26/decade), black race (HR = 1.27), and male sex (HR = 1.26). Glottic (HR = 0.75) and tonsillar or oral cavity sites (HR = 0.80) were associated with significantly (p < .0001) lower risks of SPLC. Conclusion From population-based actuarial analyses, HNSCCs with more aggressive clinicopathologic features were more apt to develop SPLC, suggestive of similar environmental and/or host factors for these cancers. (c) 2012 Wiley Periodicals, Inc. Head Neck, 2012