Clinical guidance for peripartum management of patients with hereditary thrombophilia.
Clinical guidance for peripartum management of patients with hereditary thrombophilia.
复制标题
遗传性血栓形成倾向患者围产期管理的临床指南。
DOI：
10.1111/jog.14879
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Miyata T
中科院分区：
文献类型：
--
作者：
Kobayashi T;Morishita E;Tsuda H;Neki R;Kojima T;Ohga S;Ochiai M;Adachi T;Miyata T
遗传性血栓症是一种由于遗传性缺乏抗凝血因子、抗凝血酶(AT)、蛋白C(PC)或蛋白S(PS)而容易形成血栓的疾病。许多日本血栓症患者存在PS缺乏症，特别是PS p.K196E(又称PS德岛)，这是日本人独有的，妊娠期间有时会发生血栓形成。目前，还没有针对血栓形成患者的妊娠和分娩的管理指南。遗传性血栓形成研究小组是卫生、劳工和福利科学部资助的罕见病和疑难病研究计划中凝血异常的研究小组之一，因此制定了这一临床指南，以向医护人员提供关于安全怀孕、分娩和新生儿管理的必要信息，采用了回答七个临床问题(CQ)的格式。在每个答案的末尾，会指出相应的推荐级别(A、B、C)。
Hereditary thrombophilia is a condition in which individuals are susceptible to the formation of thrombi due to a hereditary deficiency in anticoagulant factors, antithrombin (AT), protein C (PC), or protein S (PS). Many Japanese thrombophilia patients have PS deficiency, especially PS p.K196E (also called as PS Tokushima), which is exclusive to the Japanese population, and thrombosis sometimes occurs during pregnancy. At present, no management guidelines for pregnancy and delivery in thrombophilia patients have been developed. The Study Group for Hereditary Thrombophilia, one of the research groups of blood coagulation abnormalities in the Research Program on Rare and Intractable Diseases supported with the Research Grants of the Ministry of Health, Labour and Welfare Science, has therefore developed this clinical guidance to provide healthcare workers with necessary information on safe pregnancy, parturition and neonatal management, adopting a format of responses to seven clinical questions (CQ). At the end of each answer, the corresponding Recommendation Level (A, B, C) is indicated.