GENERATION OF END-INHIBITION IN THE VISUAL-CORTEX VIA INTERLAMINAR CONNECTIONS
GENERATION OF END-INHIBITION IN THE VISUAL-CORTEX VIA INTERLAMINAR CONNECTIONS
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DOI：
10.1038/320362a0
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发表时间：
1986-03-27
期刊：
影响因子：
64.8
通讯作者：
GILBERT, CD
中科院分区：
文献类型：
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作者：
BOLZ, J;GILBERT, CD
为了理解视觉皮层细胞的感受野特性是如何产生的，我们必须同时考虑丘脑对皮层的输入和皮层的内在联系。在猫纹状皮层中，第4层是外侧膝状核输入的主要受体，但该层的细胞具有几种不同于膝状核输入的接受野特性，包括定向特异性、双眼性、方向性和末端抑制，最后一种允许细胞对有限长度的边缘作出反应1 - 4。这些属性可以通过层内的连接、claustrum5的输入或第4层从第6层接收的大量投影产生（参考6 - 9）。在本研究中，我们试图通过使用抑制性递质γ-氨基丁酸（GABA）可逆地使第6层失活来确定第6层到第4层投射的功能作用。第6层失活后，第4层细胞失去末端抑制作用。第2+3层的细胞从第4层接受主要输入，它们也受到类似的影响。末端抑制的消除是特异性的，其他感受野性质，如方向选择性或定向特异性，保持不变。
To understand the mechanisms by which the receptive field properties of visual cortical cells are generated, one must consider both the thalamic input to the cortex and the intrinsic cortical connections. In the cat striate cortex, layer 4 is the main recipient of input from the lateral geniculate nucleus, yet the cells in that layer possess several receptive field properties that are distinct from the geniculate input, including orientation specificity, binocularity, directionality and end-inhibition, the last of which allows cells to respond to edges of a restricted length1–4. These properties could be generated by connections within the layer, by its input from the claustrum5or by the massive projection that layer 4 receives from layer 6 (refs 6–9). In the present study, we attempted to determine the functional role of the layer 6 to layer 4 projection by reversible inactivation of layer 6 using the inhibitory transmitterγ-aminobutyric acid (GABA). After inactivating layer 6, cells in layer 4 lost end-inhibition. Cells in layer 2+3, which receive their principal input from layer 4, were similarly affected. The elimination of end-inhibition was specific, other receptive field properties, such as direction selectivity or orientation specificity, remaining intact.