Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing mycobacterial antigen 85A and Mycobacterium bovis BCG
Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing mycobacterial antigen 85A and Mycobacterium bovis BCG
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DOI：
10.1128/iai.74.2.1416-1418.2006
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发表时间：
2006-02-01
影响因子：
3.1
通讯作者：
Xing, Z
中科院分区：
文献类型：
--
作者：
Vordermeier, HM;Huygen, K;Xing, Z
用表达分枝杆菌抗原85 A的腺病毒（rAdMA）、牛分枝杆菌BCG随后rAd 85 A异源加强或rAd 85 A随后BCG加强接种牛。BCG/rAd 85 A导致最高的直接γ干扰素应答。培养的酶联免疫斑点试验分析表明，记忆反应诱导的所有三个协议，但最强的BCG/rAd 85 A和rAd 85 A/BCG接种后。
Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAdMA), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.