Point-of-care testing.
Point-of-care testing.
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DOI：
10.1007/s11904-010-0067-z
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发表时间：
2011-03-01
影响因子：
4.6
通讯作者：
Garcia, Mary
中科院分区：
文献类型：
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作者：
Anderson, David A;Crowe, Suzanne M;Garcia, Mary
快速的护理点(POC)检测的可获得性大大扩展了发达国家和资源受限国家(RCC)诊断艾滋病毒的能力，免疫层析检测在这些环境中最常用。在农村信用社和发达国家的预防母婴传播方案中，这一点尤为重要。然而，合适的POC检测尚不能用于诊断新生儿艾滋病毒，因为婴儿中持续存在母体抗体，因此无法在最初12至18个月内使用当前的抗体检测。此外，对CD4+T细胞、CD4%和HIV病毒载量的测量仍然依赖于复杂的实验室基础设施，这限制了向许多HIV感染患者提供适当的护理。需要继续努力开发和验证其他POC测试，以支持艾滋病毒患者的护理，并在制造和现场测试性能方面提供质量保证，以确保适当使用现有和新的POC测试。
The availability of rapid, point-of-care (POC) tests has significantly expanded the capacity of both developed and resource-constrained countries (RCCs) to diagnose HIV, with immunochromatographic tests most commonly used in these settings. This has been especially important in programs for prevention of mother-to-child transmission, in both RCCs and the developed world. However, suitable POC tests are not yet commercially available for diagnosis of neonatal HIV, where persistence of maternal antibody in the infant precludes the use of current antibody tests during the first 12 to 18 months. In addition, measurement of CD4+ T cells, CD4%, and HIV viral load still relies on sophisticated laboratory infrastructure, constraining the delivery of appropriate care to many HIV-infected patients. Continued effort is required in the development and validation of additional POC tests to support HIV patient care, and in quality assurance in manufacturing and in test performance in the field to ensure appropriate use of existing and new POC tests.