FIBRINOLYTIC AND FIBRINOGEN CLOTTING ENZYMES PRESENT IN THE VENOMS OF WESTERN DIAMONDBACK RATTLESNAKE, CROTALUS-ATROX, EASTERN DIAMONDBACK RATTLESNAKE, CROTALUS-ADAMANTEUS, AND SOUTHERN PACIFIC RATTLESNAKE, CROTALUS-VIRIDIS-HELLERI
FIBRINOLYTIC AND FIBRINOGEN CLOTTING ENZYMES PRESENT IN THE VENOMS OF WESTERN DIAMONDBACK RATTLESNAKE, CROTALUS-ATROX, EASTERN DIAMONDBACK RATTLESNAKE, CROTALUS-ADAMANTEUS, AND SOUTHERN PACIFIC RATTLESNAKE, CROTALUS-VIRIDIS-HELLERI
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DOI：
10.1016/0041-0101(81)90117-3
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发表时间：
1981-01-01
期刊：
影响因子：
2.8
通讯作者：
RUSSELL, FE
中科院分区：
文献类型：
--
作者：
BAJWA, SS;MARKLAND, FS;RUSSELL, FE
在豚鼠体内，adamenteus和C. viridis helleri均具有溶纤维蛋白和纤维蛋白原凝血活性，而C. atrox具有较强的溶纤维蛋白活性，但没有检测到纤维蛋白原凝血活性。在Sephadex G-100上对粗毒液进行分离，结果表明，C. atrox具有2种单独的纤溶活性，分子量分别为60000和21500。C. adamanteus具有纤维蛋白溶解和纤维蛋白原凝血活性，在35000 MW区共同洗脱。紫锥虫具有纤溶活性，分子量为21,500，纤维蛋白原凝血活性，分子量为92,000。由于在某些涉及纤维蛋白沉积的医学疾病中，纤维蛋白溶解剂和去纤维蛋白生成剂可能的治疗应用具有临床意义，因此研究北美大陆原产于蛇的毒液中具有纤维蛋白溶解和凝血酶样活性的酶将具有价值。
Crotalus adamenteus and C. viridis helleri have both fibrinolytic and fibrinogen clotting activities in guinea pigs, whereas C. atrox has strong fibrinolytic activity but no detectable fibrinogen clotting activity. Fractionation of crude venom on Sephadex G-100 revealed that C. atrox has 2 separate fibrinolytic activities with MW of 60,000 and 21,500. C. adamanteus has fibrinolytic and fibrinogen clotting activities that co-elute in the MW region of 35,000. C. viridis helleri contains fibrinolytic activity with MW of 21,500 and fibrinogen clotting activity with a MW of 92,000. Since there is clinical interest in the possible therapeutic application of fibrinolytic and defibrinogenating agents in certain medical disorders which involve fibrin deposition, it will be of value to study enzymes with fibrinolytic and thrombin-like activity from venoms of snakes indigenous to the North American continent.