Depression and sterile inflammation: Essential role of danger associated molecular patterns
Depression and sterile inflammation: Essential role of danger associated molecular patterns
复制标题
抑郁症和无菌性炎症：危险相关分子模式的重要作用
DOI：
10.1016/j.bbi.2017.10.025
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发表时间：
2018-08-01
影响因子：
15.1
通讯作者：
Duman, Ronald S.
中科院分区：
文献类型：
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作者：
Franklin, Tina C.;Xu, Chelsea;Duman, Ronald S.
压力是包括重度抑郁症（MDD）在内的精神疾病的主要危险因素，并可诱发炎症，而炎症在抑郁症中是失调的。一些临床和临床前研究表明，抑郁症状与增加炎症的因子表达之间存在很强的关联。相反，抗炎药物的管理已被证明可以改善抑郁症状，这表明炎症作为抑郁的中介的重要性。虽然炎症在抑郁症的病理生理中起作用是明确的，但炎症在情绪障碍中激活的机制尚不清楚。为了解决这一问题，研究人员研究了模式识别受体（PRR）激活在应激性炎症和情绪障碍中的作用。然而，对内源性因子的识别，即激活这些受体的危险相关分子模式（DAMP）仍未得到充分研究。在这里，我们回顾了DAMPs在抑郁症中的作用，并强调了在重度抑郁症患者和抑郁症临床前动物应激模型中DAMPs信号升高的临床证据。(C) 2017爱思唯尔公司版权所有。
Stress is a major risk factor for psychiatric disorder including major depressive disorder (MDD) and can induce inflammation, which is known to be dysregulated in depression. Several clinical and pre-clinical studies have demonstrated a strong association between depressive symptoms and the expression of factors that increase inflammation. Conversely, administration of anti-inflammatory agents has been shown to ameliorate depressive symptoms, demonstrating the importance of inflammation as a mediator of depression. Although it is clear that inflammation plays a role in the pathophysiology of depression, the mechanism by which inflammation is activated in mood disorders remains unclear. To address this issue, studies have investigated the role of pattern recognition receptor (PRR) activation in stress-induced inflammation and mood disorders. However, the identification of the endogenous factors, referred to as danger associated molecular patterns (DAMP) that activate these receptors remains understudied. Here we review the role of DAMPs in depression and highlight the clinical evidence for elevation of DAMP signaling in MDD patients and in pre-clinical animal stress models of depression. (C) 2017 Elsevier Inc. All rights reserved.