Quinazolines. VII. Synthesis of 1,3‐Diamino‐5,6‐dihydrobenzo[f]quinazolines
Quinazolines. VII. Synthesis of 1,3‐Diamino‐5,6‐dihydrobenzo[f]quinazolines
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VII. 1,3-二氨基-5,6-二氢苯并[f]喹唑啉的合成
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
E. Modest
中科院分区：
文献类型：
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作者：
A. Rosowsky;Katherine K. N. Chen;N. Papathanasopoulos;E. Modest
Eighteen new 1,3-diamino-5,6-dihydrobenzo[f] quinazolines (6, R. = alkyl, Cl, MeO) were synthesized via the condensation of appropriate 2-tetralones with cyanoguanidine under fusion conditions. Methods were developed for the preparation of a number of heretofore undescribed 2-tetralones as precursors. The final products can be viewed as conformationally rigid analogs of pyrimethamine (2), and are of interest as inhibitors of dihydrofolate reductase and as potential antimalarial and antitumor agents.
