Variation in the distribution of trace elements in hepatoma
Variation in the distribution of trace elements in hepatoma
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DOI：
10.1385/bter:95:1:49
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发表时间：
2003-10-01
影响因子：
3.9
通讯作者：
Koide, O
中科院分区：
文献类型：
--
作者：
Tashiro, H;Kawamoto, T;Koide, O
肝脏疾病患者血清中锌水平降低和铜水平升高的报道很多。然而，目前对肝癌组织和非肿瘤组织中微量元素的比较报道较少，本文研究了肝癌组织和非肿瘤组织中微量元素的分布，并与正常肝组织进行了比较。选择锌（Zn）、铜（Cu）、硒（Se）、镉（Cd）、汞（Hg）、铁（Fe）作为微量元素进行观察，结果发现肿瘤组织中Zn、Cd、Hg含量福尔斯，Cu含量上升。肿瘤组织中Zn、Cd、Hg含量显著低于非肿瘤组织，非肿瘤组织中Zn、Cd、Hg含量显著低于正常肝组织。这一趋势是明确的镉和汞比锌。虽然铜的分布不显著，但与锌的分布相反，这些结果表明，锌，镉和汞的分布可以作为支持证据，可能是有用的肿瘤标志物。硒在肿瘤组织、非肿瘤组织和正常肝脏中的蓄积趋势基本一致。虽然在正常肝脏中观察到大多数金属之间的相关性，但在肿瘤组织中几乎没有相关性。
There are many reports of reduction of zinc level and rise of copper level in serum of patients with liver disease. However, there are a few reports that compare the trace elements in tumor tissues and nontumor tissues of the liver with hepatoma.We studied trace element distribution in tumor tissues and nontumor tissues of liver with hepatoma and compared them with data from normal liver tissues. Zinc (Zn), copper (Cu), selenium (Se), cadmium (Cd), mercury (Hg), and iron (Fe) were chosen as the trace elements to be observed.We observed falls of Zn, Cd, and Hg levels in tumor tissues and the rise of Cu level as a result of this investigation. Zn, Cd, and Hg levels in tumor tissues were significantly lower than those in nontumor tissues and Zn, Cd, and Hg levels in nontumor tissues were significantly lower than in normal liver tissues. This tendency was clearer for Cd and Hg than for Zn. Although the distribution of Cu was not significant, a distribution contrary to that of Zn was shown.These findings indicate that the distribution of Zn, Cd, and Hg can serve as supportive evidence that could be useful as a tumor marker. Selenium showed almost the same accumulation tendency among tumor tissues, nontumor tissues, and normal livers. Although correlation was observed among most metals in the normal liver, there was almost no correlation in tumor tissues.