Brain activation by umami substances via gustatory and visceral signaling pathways, and physiological significance
Brain activation by umami substances via gustatory and visceral signaling pathways, and physiological significance
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DOI：
10.1248/bpb.31.1827
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发表时间：
2008-10-01
影响因子：
2
通讯作者：
Torii, Kunio
中科院分区：
文献类型：
--
作者：
Kondoii, Takashi;Torii, Kunio
谷氨酸单钠（MSG）能产生独特的鲜味，被广泛用作各种菜肴的增味剂。最近的研究表明，在肠道粘膜和口腔中存在L-谷氨酸（GLU）受体及其转导分子。胃迷走神经传入纤维对胃中GLU的腔刺激有特异性反应。胃中的GLU给药还激活几个脑区（岛叶皮质、基底神经节、边缘系统和下丘脑）。味精的摄入增强了消化液和胰岛素的分泌。自发摄入最佳浓度（1%（w/v））的MSG溶液可降低大鼠的体重增加、脂肪沉积和血浆瘦素水平，而不影响大鼠的摄食量、鼻肛长度（躯体发育指数）和瘦体重。这些结果表明，通过味觉和内脏途径的鲜味信号可能在消化、吸收、代谢过程中发挥重要作用。和其他生理功能。
Monosodium L-glutamate (MSG) elicits a unique taste termed umami and is widely used as a flavor enhancer in a variety of cuisines. Recent studies suggest the existence of L-glutamate (GLU) receptors and its transduction molecules in the gut mucosa as well as in the oral cavity. The vagal gastric afferent fibers respond specifically to the luminal stimulation of GLU in the stomach. GLU administration in the stomach also activates several brain areas (insular cortex, basal ganglia, limbic system, and hypothalamus). Ingestion of MSG enhanced secretion of digestive Juices and insulin. Spontaneous ingestion of an MSG solution at the most preferred concentration (1% (w/v)) reduced weight gain, fat deposition, and plasma leptin levels without affecting food intake, naso-anal length (an index of somatic development), and lean mass in rats. These results suggest that umami signaling via gustatory and visceral pathways may play an important role in the process of digestion, absorption, metabolism. and other physiological functions via activation of the brain.