Dietary ortho phenols that induce glutathione S-transferase and increase the resistance of cells to hydrogen peroxide are potential cancer chemopreventives that act by two mechanisms:: the alleviation of oxidative stress and the detoxification of mutagenic xenobiotics
Dietary ortho phenols that induce glutathione S-transferase and increase the resistance of cells to hydrogen peroxide are potential cancer chemopreventives that act by two mechanisms:: the alleviation of oxidative stress and the detoxification of mutagenic xenobiotics
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DOI：
10.1016/s0304-3835(00)00368-2
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发表时间：
2000-08-11
期刊：
影响因子：
9.7
通讯作者：
Schneider, H
中科院分区：
文献类型：
--
作者：
Fiander, H;Schneider, H
氧化应激与癌症的病因有关，因此通过诱导防御自由基损伤的酶来减轻氧化应激的化合物可能可用作癌症化学预防剂。谷胱甘肽 S-转移酶 (GST) 被认为是保护细胞免受自由基损伤的关键酶的候选者，部分原因是它的诱导水平与细胞系 IMR-32 免受过氧化氢诱导的氧化应激的保护相关。本研究发现膳食邻苯酚既能诱导 GST，又能保护细胞系 IMR-32 免受过氧化氢引起的氧化应激。与许多不带酚基的 GST 诱导剂相比，邻苯酚（邻苯酚）诱导剂是更好的抗氧化应激保护剂，这可能是因为邻苯酚的苯酚残基允许其充当抗氧化剂和 GST 诱导剂。此前，GST 被认为可以通过解毒诱变异生物质来保护细胞免受癌症侵害。目前的结果表明，GST 的邻苯酚诱导剂可能可用作癌症化学预防剂，其通过两种独立的机制发挥作用，即减轻氧化应激和解毒诱变外源性物质。皇冠版权所有 (C) 2000 由 Elsevier Science Ireland Ltd 出版。
Oxidative stress is implicated in the etiology of cancer, hence compounds that alleviate oxidative stress by inducing enzymes that defend against free radical damage might be useful as cancer chemopreventives. Glutathione S-transferase (GST) has been suggested to be a candidate for a critical enzyme in protecting cells against free radical damage, in part, because its level of induction correlates with protection of the cell line IMR-32 against hydrogen peroxide-induced oxidative stress. The present study identified dietary ortho phenols that both induce GST and protect the cell line IMR-32 against hydrogen peroxide-caused oxidative stress. The ortho phenol (o-phenol) inducers were better protectors against oxidative stress than a number of GST inducers that did not bear phenolic groups, possibly because the phenol residues of the ortho phenols allowed their action as antioxidants as well as inducers of GST. GST has previously been thought to protect cells against cancer by detoxifying mutagenic xenobiotics. The present results suggest that ortho phenol inducers of GST might be useful as cancer chemopreventives that act by two independent mechanisms, the alleviation of oxidative stress and the detoxification of mutagenic xenobiotics. Crown Copyright (C) 2000 Published by Elsevier Science Ireland Ltd.