Uterine glands: biological roles in conceptus implantation, uterine receptivity and decidualization.
Uterine glands: biological roles in conceptus implantation, uterine receptivity and decidualization.
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DOI：
10.1387/ijdb.130344ts
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Spencer TE
中科院分区：
文献类型：
--
作者：
Filant J;Spencer TE
所有哺乳动物子宫在子宫内膜中都含有腺体，其合成或运输和分泌对于孕体（胚胎/胎儿和相关的胚外膜）的存活和发育至关重要的物质。本文综述了子宫腺及其分泌物在子宫容受性、胚泡/孕体存活和着床以及基质细胞蜕膜化中的生物学作用。绵羊子宫腺基因敲除（UGKO）模型的研究支持子宫腺的主要作用，并推断，它们的分泌物存在于子宫腔液组织营养细胞中，用于孕体的生存和发育。在啮齿类动物中，对突变体和孕酮诱导的UGKO小鼠的研究发现，子宫腺及其分泌物是建立子宫容受性和胚泡着床所明确需要的，也可能影响子宫中胚泡滋养外胚层活化和基质细胞蜕膜化。类似地，在人类中，来自子宫腺的组织营养细胞对于早期妊娠期间的胚泡着床、子宫容受性和孕体营养似乎至关重要，并且子宫腺可能在基质细胞蜕膜化中起作用。增加对子宫腺生物学的了解对于诊断、预防和治疗家畜和人类的生育问题，特别是不孕症和复发性流产非常重要。
All mammalian uteri contain glands in the endometrium that synthesize or transport and secrete substances essential for survival and development of the conceptus (embryo/fetus and associated extraembryonic membranes). This review summarizes information related to the biological roles of uterine glands and their secretions in uterine receptivity, blastocyst/conceptus survival and implantation, and stromal cell decidualization. Studies with the ovine uterine gland knockout (UGKO) model support a primary role for uterine glands and, by inference, their secretions present in uterine luminal fluid histrotroph for conceptus survival and development. In rodents, studies with mutant and progesterone-induced UGKO mice found that uterine glands and their secretions are unequivocally required for establishment of uterine receptivity and blastocyst implantation and also may influence blastocyst trophectoderm activation and stromal cell decidualization in the uterus. Similarly in humans, histotroph from uterine glands appears critical for blastocyst implantation, uterine receptivity, and conceptus nutrition during the first trimester and uterine glands likely have a role in stromal cell decidualization. An increased understanding of uterine gland biology is important for diagnosis, prevention and treatment of fertility problems, particularly infertility and recurrent pregnancy loss, in domestic animals and humans.
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影响因子：
3.5
作者：
Chakraborty, I;Das, SK;Dey, SK
通讯作者：
Dey, SK
影响因子：
82.9
作者：
Cha J;Sun X;Dey SK
通讯作者：
Dey SK
DOI：
10.1073/pnas.0905523106
发表时间：
2009-10-13
影响因子：
11.1
作者：
Arnaud, Estelle;Zenker, Jennifer;Chrast, Roman
通讯作者：
Chrast, Roman
影响因子：
3
作者：
Clausen, BE;Burkhardt, C;Förster, I
通讯作者：
Förster, I
影响因子：
3.3
作者：
BAZER, FW
通讯作者：
BAZER, FW