In vitro evidence for matrix regulation of intestinal epithelial biology during mucosal healing
In vitro evidence for matrix regulation of intestinal epithelial biology during mucosal healing
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DOI：
10.1016/s0024-3205(01)01408-4
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发表时间：
2001-11-09
期刊：
影响因子：
6.1
通讯作者：
Basson, MD
中科院分区：
文献类型：
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作者：
Basson, MD
我们现在知道，修复不仅仅是一个去分化和细胞在伤口缺损处随机移动的过程。事实上，这是一个有序和受调节的过程，其中肠粘膜上皮细胞采用迁移表型，涉及细胞骨架和细胞内马达的改变，可能受到整合素相关信号蛋白和下游第二信使的严格调节。细胞外基质不仅作为物理基质影响恢复，而且通过调节相关细胞内蛋白质的表达、组织和活化，以及通过调节细胞外环境中可溶性因子受体的表达和组织来影响恢复，所述可溶性因子也影响细胞运动性。由细胞骨架重排引发的机械化学信号传导的其他潜在途径有待进一步研究。出版社：Elsevier Science Inc. All rights reserved.
We now know that restitution is more than a process of dedifferentiation and random cell movement across a wound defect. In fact, it is an orderly and regulated process in which gut mucosal epithelial cells adopt a migratory phenotype involving alterations in the cytoskeleton and intracellular motors likely to be tightly regulated by integrin-associated signal proteins and downstream second messengers. The extracellular matrix influences restitution not only as a physical substrate but also by modulating the expression, organization, and activation of the relevant intracellular proteins, as well as by modulating the expression and organization of receptors for soluble factors in the extracellular environment which also influence cell motility. The additional potential avenue of mechanicochemical signaling initiated by cytoskeletal rearrangement awaits further investigation. Published by Elsevier Science Inc. All rights reserved.