Serum C-reactive protein as a prognostic indicator in patients with oral squamous cell carcinoma
Serum C-reactive protein as a prognostic indicator in patients with oral squamous cell carcinoma
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DOI：
10.1016/j.oraloncology.2009.03.015
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发表时间：
2009-10-01
期刊：
影响因子：
4.8
通讯作者：
Whitaker, Rhiannon
中科院分区：
文献类型：
--
作者：
Khandavilli, Sunil D.;Ceallaigh, Padraig O.;Whitaker, Rhiannon
术前血清C反应蛋白(CRP)升高已被证明是食道癌、胃癌和结直肠癌的预后指标。本研究旨在确定术前血清C反应蛋白水平升高是否可以预测口腔鳞状细胞癌(SCC)初次手术患者的预后。60例口腔鳞状细胞癌患者接受了一期手术和微血管游离皮瓣重建。对术前血清C反应蛋白水平、临床病理特征与患者预后的关系进行分析。这项研究通过双变量分析(p=0.003)和多变量分析(p<；0.001)显示，术前C反应蛋白升高与总体存活率下降相关。当肿瘤大小和分期与C反应蛋白水平相结合时，增加了这一指标的预测能力。(C)2009爱思唯尔有限公司。保留所有权利。
Preoperative elevation of serum C-reactive protein (CRP) has been demonstrated as a prognostic indicator in oesophageal, gastric and colorectal cancer. This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamous cell carcinoma (SCC). Sixty patients with oral SCC who were treated by primary surgery and microvascular free flap reconstruction, were included in the study. The relation between preoperative levels of serum CRP, clinicopathological features and patient prognosis was determined. This study showed using bivariate analysis (p = 0.003) and multivariate analysis (p < 0.001) that a raised preoperative CRP was associated with worse overall survival. Tumour size and stage when combined with CRP levels increases the predictive power of this indicator. (C) 2009 Elsevier Ltd. All rights reserved.