Math1 is essential for genesis of cerebellar granule neurons
Math1 is essential for genesis of cerebellar granule neurons
复制标题
DOI：
10.1038/36579
复制
发表时间：
1997-11-13
期刊：
影响因子：
64.8
通讯作者：
Zoghbi, HY
中科院分区：
文献类型：
--
作者：
BenArie, N;Bellen, HJ;Zoghbi, HY
小脑对运动和姿势的精细运动控制是必不可少的，它的功能障碍破坏了平衡，损害了对言语、肢体和眼睛运动的控制。发育中的小脑主要由三种神经细胞组成：外胚层颗粒细胞、浦肯野细胞和深核神经元(1)。这些神经元亚型的具体决定和分化背后的分子机制尚不清楚。Math1(参考文献2，3)是果蝇无性系基因(4)的小鼠同源基因，编码一种基本的螺旋-环-螺旋转录因子，该转录因子在外生发层及其衍生物的前体中特异表达。在这里，我们报告了缺乏Math1的小鼠不能形成颗粒细胞，并且出生时小脑缺乏外部生发层。据我们所知，Math1是第一个在体内被证明是颗粒细胞发生所需的基因，因此是小脑中的主要神经元群。
The cerebellum is essential for fine motor control of movement and posture, and its dysfunction disrupts balance and impairs control of speech, limb and eye movements. The developing cerebellum consists mainly of three types of neuronal cells: granule cells in the external germinal layer, Purkinje cells, and neurons of the deep nuclei(1). The molecular mechanisms that underlie the specific determination and the differentiation of each of these neuronal subtypes are unknown. Math1 (refs 2, 3), the mouse homologue of the Drosophila gene atonal(4), encodes a basic helix-loop-helix transcription factor that is specifically expressed in the precursors of the external germinal layer and their derivatives. Here we report that mice lacking Math1 fail to form granule cells and are born with a cerebellum that is devoid of an external germinal layer. To our knowledge, Math1 is the first gene to be shown to be required in vivo for the genesis of granule cells, and hence the predominant neuronal population in the cerebellum.