Respiratory Syncytial Virus Transplacental Antibody Transfer and Kinetics in Mother-Infant Pairs in Bangladesh
Respiratory Syncytial Virus Transplacental Antibody Transfer and Kinetics in Mother-Infant Pairs in Bangladesh
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DOI：
10.1093/infdis/jiu316
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发表时间：
2014-11-15
影响因子：
6.4
通讯作者：
Englund, Janet A.
中科院分区：
文献类型：
--
作者：
Chu, Helen Y.;Steinhoff, Mark C.;Englund, Janet A.
背景肺炎是全球儿童死亡的主要原因。呼吸道合胞病毒（RSV）是肺炎最重要的病毒病因。母亲血清抗体保护婴儿免受RSV疾病。我们研究的目的是表征母婴对中RSV抗体水平。方法。从孟加拉国妊娠晚期至产后72周的母婴对中采集系列血清样本，并使用RSV抗体微量中和试验进行检测。血清学感染定义为抗体滴度增加4倍。使用婴儿从出生到20周的抗体滴度计算母体抗体半衰期。在149对母婴中，婴儿脐带血与母亲血清RSV抗体滴度的比值为1.01（95%置信区间[CI]，0.99 -1.03）。母亲RSV抗体滴度在妊娠晚期和出生时有很强的相关性（R = 0.68）。抗体半衰期为38天（95% CI，36-42天）。较高的脐带血RSV抗体滴度与较低的血清学感染风险（P = .01）和抗体滴度维持在潜在保护阈值以上（P < .001）相关。在亚洲的母婴对中记录了RSV特异性抗体从母亲到胎儿的有效经胎盘转移。较高的脐带血抗体滴度与血清学感染的保护有关。
Background. Pneumonia is the leading cause of childhood mortality globally. Respiratory syncytial virus (RSV) is the most important viral cause of pneumonia. Maternal serum antibody protects infants from RSV disease. The objective of our study was to characterize RSV antibody levels in mother-infant pairs.Methods. Serial serum samples were collected from mother-infant pairs in Bangladesh from the third trimester of pregnancy to 72 weeks postpartum and tested using an RSV antibody microneutralization assay. Serologic infection was defined as a 4-fold increase in antibody titer. Maternal antibody half-life was calculated using infant antibody titers from birth to 20 weeks.Results. The ratio of infant cord blood to maternal serum RSV antibody titers in 149 mother-infant pairs was 1.01 (95% confidence interval [CI], .99-1.03). Maternal RSV antibody titers in the third trimester and at birth were strongly correlated (R = 0.68). Antibody half-life was 38 days (95% CI, 36-42 days). Higher cord blood RSV antibody titers were associated with a lower risk of serologic infection (P = .01) and maintenance of antibody titer above a potentially protective threshold (P < .001).Conclusions. Efficient transplacental transfer of RSV-specific antibody from mother to the fetus was documented in mother-infant pairs in Asia. Higher cord blood antibody titers were associated with protection from serologic infection.