Mapping joint grey and white matter reductions in Alzheimer's disease using joint independent component analysis
Mapping joint grey and white matter reductions in Alzheimer's disease using joint independent component analysis
复制标题
使用联合独立成分分析绘制阿尔茨海默病的联合灰质和白质减少图
DOI：
10.1016/j.neulet.2012.10.038
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发表时间：
2012-12-07
影响因子：
2.5
通讯作者：
Yao, Li
中科院分区：
文献类型：
--
作者：
Guo, Xiaojuan;Han, Yuan;Yao, Li
阿尔茨海默病（AD）是一种伴有灰质和白质损伤的神经退行性疾病。然而，对于 AD 中灰质和白质之间体积变化的相互关系仍然知之甚少。本研究利用联合独立成分分析，根据结构磁共振成像数据确定了灰质和白质联合体积减少，以构建 12 名 AD 患者和 14 名正常对照 (NC) 的协变网络。我们发现 AD 患者的关节灰白质来源的三个网络显示出显着的体积减少，包括（1）额叶/顶叶/颞叶-上纵束/胼胝体，（2）颞叶/顶叶/枕叶-额叶/枕叶，和（3）颞叶-中央前/中央后。相应的表达评分区分 AD 患者和 NC 患者，对联合来源 1、2 和 3 的敏感性分别为 85.7%、100% 和 85.7%；联合来源 1、2 和 3 的特异性分别为 75.0%、66.7% 和 75.0%。此外，三个重要联合来源的组合来源可以最好地预测 AD/NC 组成员资格，敏感性为 92.9%，特异性为 83.3%。我们的研究结果揭示了AD患者的灰质和白质联合减少，这些结果有助于阐明AD发展过程中灰质和白质减少的机制。 (C) 2012 Elsevier Ireland Ltd. 保留所有权利。
Alzheimer's disease (AD) is a neurodegenerative disease concomitant with grey and white matter damages. However, the interrelationship of volumetric changes between grey and white matter remains poorly understood in AD. Using joint independent component analysis, this study identified joint grey and white matter volume reductions based on structural magnetic resonance imaging data to construct the covariant networks in twelve AD patients and fourteen normal controls (NC). We found that three networks showed significant volume reductions in joint grey-white matter sources in AD patients, including (1) frontal/parietal/temporal-superior longitudinal fasciculus/corpus callosum, (2) temporal/parietal/occipital-frontal/occipital, and (3) temporal-precentral/postcentral. The corresponding expression scores distinguished AD patients from NC with 85.7%, 100% and 85.7% sensitivity for joint sources 1, 2 and 3, respectively; 75.0%, 66.7% and 75.0% specificity for joint sources 1, 2 and 3, respectively. Furthermore, the combined source of three significant joint sources best predicted the AD/NC group membership with 92.9% sensitivity and 83.3% specificity. Our findings revealed joint grey and white matter loss in AD patients, and these results can help elucidate the mechanism of grey and white matter reductions in the development of AD. (C) 2012 Elsevier Ireland Ltd. All rights reserved.