ILCs and Allergy
ILCs and Allergy
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DOI：
10.1007/978-981-16-8387-9_6
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发表时间：
2022-01-01
期刊：
影响因子：
--
通讯作者：
Moro, Kazuyo
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文献类型：
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作者：
Kabata, Hiroki;Motomura, Yasutaka;Moro, Kazuyo
最近发现的新的先天淋巴样细胞（ILCs）已经彻底改变了过敏领域。由于大多数过敏性疾病诱导2型免疫反应，Th2细胞以抗原依赖的方式产生IL-4、IL-5和IL-13，以及嗜碱性细胞和肥大细胞被抗原特异性IgE激活，被认为在发病机制中起主要作用。然而，由于2组先天淋巴样细胞（ILC2s）对周围环境中包括IL-33在内的各种细胞因子产生2型细胞因子（即IL-2、IL-4、IL-5、IL-6、IL-9、IL-13、GM-CSF和双调节蛋白），因此可能存在两种类型的过敏：Th2细胞以抗原依赖性方式诱导的过敏和ILC2s以抗原非依赖性方式诱导的过敏。为了对世界上日益增加的过敏性疾病发病率产生影响，研究和开发不仅关注Th2细胞而且关注ILC2s的新治疗方法至关重要。本章主要讨论了随着ILCs的发现而迅速改变的ILCs在变应性疾病中的作用，主要集中在ILC2s上。
The recent discovery of new innate lymphoid cells (ILCs) has revolutionized the field of allergies. Since most allergic diseases induce a type 2 immune response, Th2 cells, which produce IL-4, IL-5, and IL-13 in an antigen-dependent manner, in addition to basophils and mast cells which are activated by antigen-specific IgE, are thought to play a major role in the pathogenesis. However, since group 2 innate lymphoid cells (ILC2s) produce type 2 cytokines (i.e., IL-2, IL-4, IL-5, IL-6, IL-9, IL-13, GM-CSF, and amphiregulin) in response to various cytokines, including IL-33 in the surrounding environment, the possibility has emerged that there are two types of allergies: allergies induced in an antigen-dependent manner by Th2 cells and allergies induced in an antigen-independent manner by ILC2s. In order to make an impact on the increasing incidence of allergic diseases in the world, it is essential to research and develop new treatments that focus not only on Th2 cells but also on ILC2s. In this chapter, the role of ILCs in allergic diseases, which has rapidly changed with the discovery of ILCs, is discussed, focusing mainly on ILC2s.