Cancer incidence among Finnish world class male athletes
Cancer incidence among Finnish world class male athletes
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DOI：
10.1055/s-2000-8878
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发表时间：
2000-04-01
影响因子：
2.5
通讯作者：
Sarna, S
中科院分区：
文献类型：
--
作者：
Pukkala, E;Kaprio, J;Sarna, S
通过芬兰癌症登记处对1920-1965年间2269名男性世界级运动员的癌症发病率进行了跟踪调查。全国癌症发病率预期值为404例，标化发病率比为0.82，95%可信区间为0.73~0.91。患肺癌的风险降低(SIR 0.35，95%CI 0.25-0.48)，尤其是耐力运动员(0.12，0.01-0.41)，这与运动员吸烟的低患病率很好地吻合。肾癌的SIR也很低(0.43，0.16-0.93)，可能部分是因为更好的饮食(更多的蔬菜，更少的脂肪)。与吸烟无关的癌症发病率没有下降。在整个队列中，没有一个癌症部位显示出明显的过量，但跨栏运动员患骨肉瘤和软组织肉瘤的相对风险显着高，根据暗示的因果机制，这可能与他们活跃运动期间的伤害有关。这一点以及其他没有合理的先验假设的观察结果需要在更详细的分析和其他数据集中得到证实，然后才能得出最终结论。
A cohort of 2269 male world class athletes from the years 1920-65 was followed up through the Finnish Cancer Registry for cancer incidence during 1967-95. There were 331 cases of cancer while the expected number based on the national cancer incidence rates was 404; the standardized incidence ratio (SIR) was 0.82 and its 95% confidence interval (CI) 0.73-0.91. There was a decreased risk of cancers of the lung (SIR 0.35, 95% CI 0.25-0.48), especially among endurance athletes (0.12, 0.01-0.41), This fits well with the low prevalence of smoking among the athletes. The SIR for kidney cancer was also significantly low (0.43, 0.16-0.93), possibly partly due to the better diet (more vegetables, less fat). Incidence of cancers not related to smoking was not reduced. None of the cancer sites showed a significant excess in the whole cohort but hurdlers had a significantly high relative risk of sarcomas of the bone and soft tissue which according to suggested causal mechanisms might be related e.g. to injuries during their active sport period. This as well as other observations without sound a priori hypotheses needs to be confirmed in more detailed analyses and in other data sets before final conclusions.