Mendelian randomization suggests a causal relationship between gut dysbiosis and thyroid cancer.
Mendelian randomization suggests a causal relationship between gut dysbiosis and thyroid cancer.
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DOI：
10.3389/fcimb.2023.1298443
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发表时间：
2023
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
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作者：
肠道微生物区系组成和功能的改变与甲状腺癌(TC)的发生和发展有关。然而，它们之间的因果关系的确切性质仍然不确定。采用双向两样本孟德尔随机化(TSMR)分析，利用全基因组关联研究(GWAS)的数据，评估肠道微生物区系(18,340人)和TC(6,699例病例和1,613,655例对照)之间的因果联系。初步分析采用逆方差加权(IVW)方法估计因果效应，辅以加权中位数、加权模型、简单模型和MR-Egger方法。用Cochrane Q检验、MR-Egger截距检验和MR-PRESSO整体检验评价异质性和多效性。进行反向TSMR分析以探索反向因果关系。这项研究确定了七个与TC显著相关的微生物分类群。其中丁状弧菌属(OR：1.127，95%CI：1.008~1.260，p=0.036)、镰刀菌属(OR：1.313，95%CI：1.066~1.618，p=0.011)、振荡杆菌属(OR：1.240，95%CI：1.001~1.536，p=0.049)、反胃球菌2(OR：1.408，95%CI：1.158~1.711，p<；与TC风险相关的危险因素为欧氏杆菌属(OR：0.882，95%CI：0.787~0.989，p=0.031)和瘤胃球菌科UCG004(OR：0.719，95%CI：0.566~0.914，p=0.031)。反向MR分析没有发现反向因果关系的证据，提示TC可能导致霍尔德曼氏菌属水平的增加(β：0.053，95%CI：0.012~0.094，p=0.011)和杆菌目水平的下降(β：-0.075，95%CI：-0.143~-0.006，p=0.033)。在这项研究中没有发现显著的偏倚、异质性或多效性。这项研究提出了肠道微生物区系与TC之间的潜在因果关系，为肠道微生物区系在TC中的作用提供了新的见解。需要进一步的研究来探索潜在的生物学机制。
Alterations in gut microbiota composition and function have been linked to the development and progression of thyroid cancer (TC). However, the exact nature of the causal relationship between them remains uncertain. A bidirectional two-sample Mendelian randomization (TSMR) analysis was conducted to assess the causal connection between gut microbiota (18,340 individuals) and TC (6,699 cases combined with 1,613,655 controls) using data from a genome-wide association study (GWAS). The primary analysis used the inverse-variance weighted (IVW) method to estimate the causal effect, with supplementary approaches including the weighted median, weighted mode, simple mode, and MR-Egger. Heterogeneity and pleiotropy were assessed using the Cochrane Q test, MR-Egger intercept test, and MR-PRESSO global test. A reverse TSMR analysis was performed to explore reverse causality. This study identified seven microbial taxa with significant associations with TC. Specifically, the genus Butyrivibrio (OR: 1.127, 95% CI: 1.008-1.260, p = 0.036), Fusicatenibacter (OR: 1.313, 95% CI: 1.066-1.618, p = 0.011), Oscillospira (OR: 1.240, 95% CI: 1.001-1.536, p = 0.049), Ruminococcus2 (OR: 1.408, 95% CI: 1.158-1.711, p < 0.001), Terrisporobacter (OR: 1.241, 95% CI: 1.018-1.513, p = 0.032) were identified as risk factors for TC, while The genus Olsenella (OR: 0.882, 95% CI: 0.787-0.989, p = 0.031) and Ruminococcaceae UCG004 (OR: 0.719, 95% CI: 0.566-0.914, p = 0.007) were associated with reduced TC risk. The reverse MR analysis found no evidence of reverse causality and suggested that TC may lead to increased levels of the genus Holdemanella (β: 0.053, 95% CI: 0.012~0.094, p = 0.011) and decreased levels of the order Bacillales (β: -0.075, 95% CI: -0.143~-0.006, p = 0.033). No significant bias, heterogeneity, or pleiotropy was detected in this study. This study suggests a potential causal relationship between gut microbiota and TC, providing new insights into the role of gut microbiota in TC. Further research is needed to explore the underlying biological mechanisms.
影响因子：
6
作者：
Sagaram M;Royer AJ;Hu H;Rajhans A;Parthasarathy R;Krishnasamy SS;Mokshagundam SP;Kong M;Schwandt ML;Parajuli D;Cave MC;Vatsalya V
通讯作者：
Vatsalya V