Inhibition of oxygen consumption by pentachlorophenol and tetrachloroguaiacol in rainbow trout (Oncorhynchus mykiss)
Inhibition of oxygen consumption by pentachlorophenol and tetrachloroguaiacol in rainbow trout (Oncorhynchus mykiss)
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DOI：
10.1016/s0166-445x(00)00162-4
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发表时间：
2001-09-01
影响因子：
4.5
通讯作者：
McKinley, RS
中科院分区：
文献类型：
--
作者：
Brodeur, JC;Dixon, DG;McKinley, RS
将虹鳟鱼（Oncorhynchus mj，kiss）暴露于五氯酚（PCP）或四氯愈创木酚（TCG）96 h-LC 50的100、50和25%浓度下24 h，定期测定其耗氧量、心输出量、心率和每搏输出量。当鱼暴露于每种化学品的96 h-LC 50时，耗氧量要么保持稳定在基础水平（PCP），要么增加到基础水平的130%（TCG）。然而，当鱼类暴露于五氯苯酚或三氯苯酚浓度（分别为96小时半数致死浓度的50%和25%）时，耗氧量降至基础水平的50-60%。由于心输出量、心率和每搏输出量保持稳定，因此耗氧量的降低似乎不会影响心脏功能。五氯苯酚最为人所知的是其能够解偶联氧化磷酸化并增加耗氧量。然而，本研究表明，它也可以降低耗氧量，PCP和TCG对鱼类代谢的影响相似。(C)2000 Elsevier Science B. V.保留所有权利。
Rainbow trout (Oncorhynchus mj,kiss) were exposed for 24 h to concentrations representing 100, 50 and 25% of the 96 h-LC50 of pentachlorophenol (PCP) or tetrachloroguaiacol (TCG), and their oxygen consumption, cardiac output, heart rate and stroke volume were measured at regular intervals. oxygen consumption either remained stable at basal levels (PCP), or increased to 130% of basal levels (TCG) when fish were exposed to the 96 h-LC50 of each chemical. However, oxygen consumption decreased to about 50-60% of basal levels when fish were exposed to concentrations of PCP or TCG representing 50 and 25% of the 96 h-LC50. This decrease in oxygen consumption did not appear to affect cardiac function since cardiac output, heart rate and stroke volume remained stable. PCP is best known for its capacity to uncouple oxidative phosphorylation and increase oxygen consumption. However, this study showed that it can also decrease oxygen consumption, and that the effects of PCP and TCG on fish metabolism are similar. (C) 2000 Elsevier Science B.V. All rights reserved.