Attenuated activation of the anterior rostral medial prefrontal cortex on self-relevant social reward processing in individuals with autism spectrum disorder
Attenuated activation of the anterior rostral medial prefrontal cortex on self-relevant social reward processing in individuals with autism spectrum disorder
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DOI：
10.1016/j.nicl.2020.102249
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发表时间：
2020-01-01
影响因子：
4.2
通讯作者：
Sadato, Norihiro
中科院分区：
文献类型：
--
作者：
Sumiya, Motofumi;Okamoto, Yuko;Sadato, Norihiro
社会动机假说认为，自闭症谱系障碍（ASD）患者发现社会刺激的回报较少，因此与神经典型发育（TD）的人相比，他们对社会互动的动机较低。然而，ASD患者在社交互动过程中的奖励较少的社会刺激特征在很大程度上是未知的。与自我行动相关的其他人的偶然积极反应激发了社会互动的早期发展，因此代表了社会奖励。由于ASD患者在其早期生活中经常对自我相关刺激表现出非典型反应，因此我们假设他人的自我相关反应对ASD患者的回报较少。为了验证这一假设，我们进行了一项功能磁共振成像研究，使用社会权变任务。在任务期间，参与者试图通过讲有趣的笑话来使观众发笑，从而激活TD个体的前喙内侧前额叶皮层（arMPFC）（Sumiya等人，2017年）。我们明确预测，arMPFC的非典型激活与ASD患者对他人的自我相关反应的奖励值降低有关。31名ASD成年人和24名年龄和智力匹配的TD成年人参加了这项研究。ASD的参与者报告说，在观众对他们自己的行为做出反应后，他们的快乐程度显着低于TD组。相应地，与TD组相比，ASD组中arMPFC的自身相关激活（由我们先前研究的结果定义）减弱。目前的研究结果表明，弱的自我相关的结果处理介导的arMPFC的个体与ASD抑制社会互动的奖励性质。
The social motivation hypothesis posits that people with autism spectrum disorder (ASD) find social stimuli less rewarding and are therefore less motivated towards social interaction than people with neuro-typical development (TD). However, the less rewarding social stimuli characteristics during social interaction for people with ASD are largely unknown. The contingent positive responsiveness of others relevant to self-action motivates the early development of social interaction, thus representing a social reward. As individuals with ASD often exhibit atypical responses to self-relevant stimuli in their early life, we hypothesized that the self-relevant responses of others are less rewarding for individuals with ASD. To test this hypothesis, we conducted a functional magnetic resonance imaging study using a social contingency task. During the task, the participants attempted to make the audience laugh by telling funny jokes and thus activating the anterior rostral medial prefrontal cortex (arMPFC) of TD individuals (Sumiya et al., 2017). We explicitly predicted that the atypical activation of the arMPFC is related to the reduced reward value of self-relevant responses to others in individuals with ASD. Thirty-one adults with ASD and 24 age- and intelligence quotient-matched TD adults participated in the study. Participants with ASD reported significantly lower pleasure after the audience's responses to their own actions than those in the TD group. Correspondingly, the self-related activation of the arMPFC, defined by the results of our previous study, was attenuated in the ASD group compared to the TD group. The present findings indicate that weak self-relevant outcome processing mediated by the arMPFC of individuals with ASD dampens the rewarding nature of social interaction.