The role of endotoxin in protection of adult rats from oxygen-induced lung toxicity.
The role of endotoxin in protection of adult rats from oxygen-induced lung toxicity.
复制标题
内毒素在保护成年大鼠免受氧诱导的肺毒性中的作用。
DOI：
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发表时间：
1978
影响因子：
15.9
通讯作者：
R. Roberts
中科院分区：
文献类型：
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作者：
L. Frank;J. Yam;R. Roberts
成年大鼠连续暴露于高氧（96- 98%O2）72小时后显示严重肺损伤的证据。用Plasmanate溶液（无意中被内毒素产生微生物污染）或纯化内毒素本身处理成年大鼠，显著改变了与高氧暴露相关的肺毒性（处理动物的存活率= 110/113 [97%]，未处理动物的存活率= 56/172 [33%]）。高氧暴露72小时后，内毒素处理的大鼠表现出肺超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶活性显着增加，未处理的成年大鼠中未观察到的保护酶反应。内毒素对高氧肺损伤的保护作用的基础被认为与肺抗氧化酶防御系统活性的刺激增加有关。推测内毒素的一些先前已知的作用也通过对抗高浓度O2对肺的一些通常的有害作用而起到保护作用。
Adult rats show evidence of severe lung damage after 72h of continuous exposure to hyperoxia (96-98% O2). Treatment of adult rats with a solution of Plasmanate, inadvertently contaminated with endotoxin-producing organisms, or with purified endotoxin itself markedly altered the lung toxicity associated with hyperoxic exposure (survival in treated animals = 110/113 [97%] versus survival in untreated animals = 56/172 [33%]). After 72h of hyperoxic exposure, the endotoxin-treated rats demonstrated significant increases in lung superoxide dismutase, catalase, and glutathione peroxidase activity, a protectant enzyme response not seen in untreated adult rats. The basis for endotoxin's protective effect from hyperoxic lung damage is believed to be related to the stimulated increase in activity of the pulmonary antioxidant enzyme defense system. Some previously known actions of endotoxin are speculated to also serve a protective function by opposing some of the usual detrimental effects of high concentrations of O2 on the lung.