ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF LIPID-RICH CARCINOMA OF THE BREAST
ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF LIPID-RICH CARCINOMA OF THE BREAST
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DOI：
10.1007/bf00716986
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发表时间：
1988-01-01
期刊：
影响因子：
--
通讯作者：
HOLZNER, JH
中科院分区：
文献类型：
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作者：
WRBA, F;ELLINGER, A;HOLZNER, JH
本文对5例乳腺富脂癌进行了超微结构和免疫组化研究，检测了α-乳白蛋白（ALA）、乳铁蛋白（Lfr）和人乳脂球膜抗原（HMFG-2）。ALA和Lfr染色显示几乎所有的肿瘤细胞上的强烈反应，而HMFG-2的免疫反应在单个细胞中显示阳性。所有肿瘤均为类固醇受体含量阴性。超微结构肿瘤细胞显示许多胞浆内的非膜结合的脂滴，这是经常发现的自噬空泡。无论是粗面内质网还是高尔基复合体都没有显示出任何脂质合成的迹象。未观察到脂滴挤出和细胞外脂质沉积。总之，我们的研究结果并不能证明富脂乳腺癌是一组明确定义的具有特异性分泌活性的肿瘤。因此，除非有证据表明脂质分泌活跃，否则应优先使用富脂癌一词。
Five cases of lipid-rich carcinomas of the breast were investigated ultrastructurally and immunohistochemically for alpha-lactalbumin (ALA), lactoferrin (Lfr) and human milk fat globule membrane antigen (HMFG-2). Staining for ALA and Lfr showed intensive reaction on nearly all of the tumour cells whereas immunoreaction for HMFG-2 revealed positivity in single cells. All tumours were negative for steroid receptor content. Ultrastructurally the tumour cells showed numerous intracytoplasmic non-membrane bound lipid droplets which were often found within autophagocytic vacuoles. Neither rough endoplasmic reticulum nor Golgi complexes showed any sign of lipid synthesis. Extrusion of lipid droplets and extracellular lipid deposition was not observed. In conclusion, our findings do not justify the consideration of lipid-rich carcinoma of the breast as a clearly defined group of tumours with specific secretory activity. Therefore, the term lipid-rich carcinoma should be used in preference to lipid-secreting, unless there is evidence of active lipid secretion.